Total T Cell Density and Expression of T Memory Stem Cell Markers are Associated with Better Prognosis in Colon Cancer

Ding, Jiong; Wang, Hao; Huang, Rui; Shi, Yuxin; Fan, Honghong; Li, Yuting; Mei, Jie; Ruan, Tingyan; Xu, Junying

doi:10.2147/ijgm.s411122

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…5,6 In the present study, we clearly We also found that NPC patients with CD27-positive TILs exhibited better survival than patients without such cells. Consistent with our findings, recent studies by other researchers showed a correlation between the presence of CD27-positive TILs and a favorable prognosis in some solid tumors, [28][29][30] suggesting that CD27-positive immune cells may include lymphocytes capable of eliciting antitumor immune responses, such as tumor-specific cytotoxic and helper T cells.…”

Section: Discussionsupporting

confidence: 92%

Soluble CD27 as a predictive biomarker for intra‐tumoral CD70/CD27 interaction in nasopharyngeal carcinoma

Nagato,

Komatsuda,

Hayashi

et al. 2024

Cancer Science

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In CD70‐expressing tumors, the interaction of CD70 on tumor cells with its lymphocyte receptor, CD27, is thought to play a role in immunosuppression in the tumor microenvironment and elevated serum levels of soluble CD27 (sCD27). Previous studies showed that CD70 is expressed in nasopharyngeal carcinoma (NPC), an Epstein–Barr virus (EBV)‐related malignancy. However, the association between intratumoral CD70/CD27 expression and serum levels of sCD27 in NPC remains unclear. In the present study, we show that CD70 is primarily expressed by tumor cells in NPC and that CD27‐positive lymphocytes infiltrate around tumor cells. NPC patients with CD27‐positive lymphocytes had significantly better prognosis than patients lacking these cells. In addition, high CD70 expression by tumor cells tended to be correlated with shorter survival in NPC patients with CD27‐positive lymphocytes. Serum sCD27 levels were significantly increased in patients with NPC and provided good diagnostic accuracy for discriminating patients from healthy individuals. The concentration of serum sCD27 in patients with CD70‐positive NPC with CD27‐positive lymphocytes was significantly higher than in patients with tumors negative for CD70 and/or CD27, indicating that the intratumoral CD70/CD27 interaction boosts the release of sCD27. Furthermore, positive expression of CD70 by NPC cells was significantly correlated with EBV infection. Our results suggest that CD70/CD27‐targeted immunotherapies may be promising treatment options and that sCD27 may become an essential tool for evaluating the applicability of these therapies by predicting the intratumoral CD70/CD27 interaction in NPC.

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Section: Discussionsupporting

confidence: 92%

Soluble CD27 as a predictive biomarker for intra‐tumoral CD70/CD27 interaction in nasopharyngeal carcinoma

Nagato,

Komatsuda,

Hayashi

et al. 2024

Cancer Science

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CD27 exhibits clinical diagnostic value and reveals the immune heterogeneity as well as predicts clinical drug responses in hashimoto's thyroiditis

Dong,

Bao

2023

Preprint

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Hashimoto's thyroiditis (HT), recognized as chronic lymphocytic thyroiditis, is a widespread autoimmune malady predominantly impacting females in the youthful and middle-age demographics. Initially, HT can present as hyperthyroidism, and as the disease progresses, it may transition to hypothyroidism. Studies have indicated that HT pathogenesis involves multiple factors, comprising genetic predisposition, environmental triggers, and autoimmune processes. However, the exact mechanism underlying the development of HT remains unclear. Within the framework of our study, we aimed to identify key genes and potential molecular mechanisms underlying HT, with the objective of offering fresh insights into diagnostic and therapeutic targets for this condition. To accomplish this, we amalgamated datasets GSE138198 and GSE54958 as our training cohorts, and subsequently conducted analyses encompassing the identification of differentially expressed genes (DEGs) and weighted gene co-expression network analysis (WGCNA) to pinpoint the DEGs most intricately associated with HT. Subsequently, we employed protein-protein interaction (PPI) network analysis to ascertain hub genes. We then proceeded to validate the diagnostic efficacy of these hub genes through the utilization of receiver operating characteristic (ROC) curves and nomograms. Finally, CD27 was selected as the key genes in HT and validated using clinical samples. More importantly, in order to delve deeper into the role and potential mechanisms associated with CD27 in HT, we conducted a comprehensive array of analyses including GO, KEGG and GSEA enrichment analysis, and HT-infiltrating immune cells (HTICs) components as well as functions were performed between high CD27 and low-CD27 cohorts. The findings revealed that CD27 is highly expressed in HT tissues and has important clinical application value for HT. The CD27 expression in high-cohort exhibited a more pronounced enrichment in immune-related biological processes compared to the low-expression cohort. Furthermore, we conducted CIBERSORT analysis to assess the proportion of HTICs, revealing a strong association between several activated HTICs and CD27 expression. This implies that CD27 has the potential to serve as an indicator of the immune status in individuals with Hashimoto's thyroiditis. Consequently, CD27 plays a significant role in predicting clinical outcomes in HT patients, encompassing the overall condition of HT patients and their response to immunotherapy. Furthermore, CD27 holds promise as a valuable biomarker for reshaping the microenvironment in Hashimoto's thyroiditis. This suggests potential underlying mechanisms contributing to the pathogenesis and progression of HT. Such insights may offer novel perspectives for HT treatment, ultimately leading to enhanced therapeutic strategies and improved patient care.

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GRASLND is a prognostic biomarker and associated with immune infiltration in bladder cancer

Li,

Fu,

et al. 2024

Preprint

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GRASLND has been shown to be a potent biomarker in a variety of cancers. However, studies on GRASLND and bladder cancer have been limited. Therefore, this study aimed to analyze the expression of GRASLND and their relationship with clinicopathological features, prognosis and immune cell infiltration in patients of bladder cancer. The RNA sequencing data and clinical information of 412 patients with bladder cancer and 19 normal subjects were obtained from The Cancer Genome Atlas database. Our results demonstrated that GRASLND was highly expressed in bladder cancer (P < 0.001) and could effectively distinguish bladder cancer tissue from normal bladder tissue (area under the curve = 0.805). Moreover, the expression of GRASLND was significantly correlated with pathologic stage, pathologic T stage, pathologic N stage, histologic grade and subtype. Kaplan–Meier curves analysis revealed that patients with high gene expression had shorter overall survival and worse prognosis (hazard ratio = 1.46, P = 0.012). Cox regression analysis indicated that GRASLND expression, Age, Pathologic T stage, Pathologic N stage, Pathologic M stage, Pathologic stage and Subtype were risk factors for overall survival. Immunoinfiltration analysis found that the expression of GRASLND was positively correlated with the enrichment abundance of immune cells such as macrophages, Tgd and Tem. Collectively, our results suggested that GRASLND may be an important biomarker for the diagnosis and predicting prognosis of bladder cancer, and may even be a new therapeutic target.

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Total T Cell Density and Expression of T Memory Stem Cell Markers are Associated with Better Prognosis in Colon Cancer

Cited by 4 publications

References 29 publications

Soluble CD27 as a predictive biomarker for intra‐tumoral CD70/CD27 interaction in nasopharyngeal carcinoma

Soluble CD27 as a predictive biomarker for intra‐tumoral CD70/CD27 interaction in nasopharyngeal carcinoma

CD27 exhibits clinical diagnostic value and reveals the immune heterogeneity as well as predicts clinical drug responses in hashimoto's thyroiditis

GRASLND is a prognostic biomarker and associated with immune infiltration in bladder cancer

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