Total Urinary Porphyrins

Schlenker, Frank S.; Taylor, N F; Kitchell, Cynthia L.

doi:10.1093/ajcp/44.2.189

Am J Clin Pathol

1965

DOI: 10.1093/ajcp/44.2.189

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Total Urinary Porphyrins

Frank S. Schlenker

N F Taylor

Cynthia L. Kitchell

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1966

1968

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Cited by 3 publications

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“…and collaborators (3)(4)(5)(6)(7) using "Florisil" adsorption and elution of porphyrins and spectrophotometry between 380-430 mp (Soret band) in a Beckman Model DU spectrophotometer. The material consisted of 82 urine samples, 68 of which were 24-hour specimens and 14 random specimens collected from 18 patients with sickle cell disease including 8 during painful crises.…”

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confidence: 99%

Increased Urinary Porphyrin Excretion in Sickle Cell Crises

Naumann

Diggs

Schlenker

et al. 1966

Experimental Biology and Medicine

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Urines voided during painful sickle cell crises show a characteristic dark brown coloration even though urinary secretion is voluminous and of low specific gravity( 1). The depth of color is further intensified on standing and/or exposure to sunlight. On illumination with Wood's light one of the authors (H.N.N.) observed brilliant magenta fluorescence of sediments suggesting presence of adsorbed porphyrins which, subsequently, were confirmed by qualitative extraction methods ( 2 ) . A quantitative study was then undertaken in order to determine ranges of urinary porphyrins and their precursors excreted during and after typical painful and febrile crises and in patients with sickle cell disease hospitalized for conditions other than painful crisis.Materials and methods. Patients with sickle cell disease were made available for this study through the "Sickle

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confidence: 99%

Increased Urinary Porphyrin Excretion in Sickle Cell Crises

Naumann

Diggs

Schlenker

et al. 1966

Experimental Biology and Medicine

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The clinical chemistry of the porphyrias

With

1967

Clinical Biochemistry

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Quantitative and fractional porphyrin analysis in urine

With

1968

Clinical Biochemistry

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Total Urinary Porphyrins

Cited by 3 publications

References 0 publications

Increased Urinary Porphyrin Excretion in Sickle Cell Crises

Increased Urinary Porphyrin Excretion in Sickle Cell Crises

The clinical chemistry of the porphyrias

Quantitative and fractional porphyrin analysis in urine

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