Totally Organic Hydrogel‐Based Self‐Closing Cuff Electrode for Vagus Nerve Stimulation (Adv. Healthcare Mater. 23/2022)

Terutsuki, Daigo; Yoroizuka, Hayato; Osawa, Shin‐ichiro; Ogihara, Yuka; Abe, Hiroya; Nakagawa, Atsuhiro; Iwasaki, Masaki; Nishizawa, Masatoyo

doi:10.1002/adhm.202270142

Cited by 5 publications

(7 citation statements)

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“…The extremely thin device with 1.0 mm tubes will expand the range of biomedical applications including insertion into narrow in vivo structures as a catheter, and integration with other flexible implanted devices. [ 32–36 ] The pictures in Figure 4g are the visual demonstrations of deep insertion into a brain model made of agarose and integration with a hydrogel‐based subdural electrode. [ 34 ] The totally organic format of the present hydrogel‐based delivery device is compatible with MRI imaging due to the minimum image artifacts of organic materials even in high frequency magnetic fields.…”

Section: Resultsmentioning

confidence: 99%

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Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels

Terutsuki,

Miyazawa,

Takagi

et al. 2023

Adv Funct Materials

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Spatiotemporally controlled chemical delivery is crucial for various biomedical engineering applications. Here, a novel concept of electrically controllable delivery utilizing electroosmotic flow (EOF) generated in a combination of anionic and cationic hydrogels (A‐ and C‐hydrogels) is reported. The unique advantages of the A/C‐hydrogel combination are demonstrated utilizing a flexible sheet‐shaped and a thin tubular devices. Since the directions of EOF in the A‐ and C‐hydrogels are opposite to each other, the ionic current for EOF generation flows inside the delivery devices, enabling chemical delivery without accompanying external ionic current that could stimulate target cells and tissues. A thin tubular device, which can be inserted into narrow in vivo structures and be integrated with other flexible devices, exhibits high robustness and repeatability thanks to the flexibility and water retentivity of hydrogels. The EOF devices with A/C‐hydrogels combination show high controllability superior to the pumping with a conventional syringe; the volumetric flow rate is able to be controlled proportionally to the current applied, for example, ≈0.4 µL (mA min)−1 for the tubular device. The developed EOF‐based devices are versatile for delivery of most chemicals regardless of their charge and size, and have great potential for both biomedical researches and therapeutics.

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Section: Resultsmentioning

confidence: 99%

“…[ 34 ] The totally organic format of the present hydrogel‐based delivery device is compatible with MRI imaging due to the minimum image artifacts of organic materials even in high frequency magnetic fields. [ 34–36 ]…”

Section: Resultsmentioning

confidence: 99%

Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels

Terutsuki,

Miyazawa,

Takagi

et al. 2023

Adv Funct Materials

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“…Recently, Terutsuki et al demonstrated self-closing cuff neural electrodes by sandwiching a PEDOT/polyurethane (PU) film between two curling layers of a PVA hydrogel (Figure 7d). [88] These electrodes have a low contact impedance and large electric capacitance; so that, it can ensure safe stimulation to the vagus nerve without any Faradaic reaction.…”

Section: Neural Interfaces For Peripheral Nervous Systemmentioning

confidence: 99%

Section: Mechanical Sensorsmentioning

confidence: 99%

Bioelectronic Applications of Intrinsically Conductive Polymers

Gao

Bao

Chen

et al. 2023

Adv Elect Materials

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Since the discovery of conducting polyacetylene in the 1970s, intrinsically conducting polymers (ICPs) have attracted great attention because of their interesting structure, properties, and applications. Notably different from conventional conductors such as metals and doped semiconductors, ICPs have high mechanical flexibility and are light weight. In addition, their properties can be easily tuned by controlling the doping level, modifying the chemical structure, or forming composites with organic or inorganic materials. Their application in bioelectronics is particularly interesting because they have good biocompatibility and good mechanical matching with biological tissues. In this article, the methods to increase the mechanical stretchability of ICPs are first reviewed because high stretchability is often required for bioelectronic applications while pristine ICPs generally have limited stretchability. The application of ICPs as stretchable electrodes for epidermal biopotential detection and neural interfaces is discussed. Then, the employment of ICPs as the electrodes or sensing material of mechanical sensors is reviewed. They also have important application in controllable drug delivery. Last, their applications in the wearable energy harvesting and storage devices including thermoelectric generators and supercapacitors are also covered.

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“…[ 10,11,25–27 ] Other cuff electrodes are already pre‐folded using fabrication‐induced stress and have to be manually unfolded during the attachment, where they then wrap themselves around the nerve when released. [ 28–30 ] The difficulty of this procedure further increases with the reduction of the cuff size. Thus, a manual operation on smaller and more delicate nerves brings along an increased risk of nerve damage.…”

Section: Introductionmentioning

confidence: 99%

4D‐Printed Soft and Stretchable Self‐Folding Cuff Electrodes for Small‐Nerve Interfacing

et al. 2023

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Peripheral nerve interfacing (PNI) has a high clinical potential for treating various diseases, such as obesity or diabetes. However, currently existing electrodes present challenges to the interfacing procedure, which limit their clinical application, in particular, when targeting small peripheral nerves (<200 µm). To improve the electrode handling and implantation, a nerve interface that can fold itself to a cuff around a small nerve, triggered by the body moisture during insertion, is fabricated. This folding is achieved by printing a bilayer of a flexible polyurethane printing resin and a highly swelling sodium acrylate hydrogel using photopolymerization. When immersed in an aqueous liquid, the hydrogel swells and folds the electrode softly around the nerve. Furthermore, the electrodes are robust, can be stretched (>20%), and bent to facilitate the implantation due to the use of soft and stretchable printing resins as substrates and a microcracked gold film as conductive layer. The straightforward implantation and extraction of the electrode as well as stimulation and recording capabilities on a small peripheral nerve in vivo are demonstrated. It is believed that such simple and robust to use self‐folding electrodes will pave the way for bringing PNI to a broader clinical application.

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Totally Organic Hydrogel‐Based Self‐Closing Cuff Electrode for Vagus Nerve Stimulation (Adv. Healthcare Mater. 23/2022)

Cited by 5 publications

References 0 publications

Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels

Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels

Bioelectronic Applications of Intrinsically Conductive Polymers

4D‐Printed Soft and Stretchable Self‐Folding Cuff Electrodes for Small‐Nerve Interfacing

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