Totally Organic Hydrogel‐Based Self‐Closing Cuff Electrode for Vagus Nerve Stimulation

Terutsuki, Daigo; Yoroizuka, Hayato; Osawa, Shin-ichiro; Ogihara, Yuka; Abe, Hiroya; Nakagawa, Atsuhiro; Iwasaki, Masaki; Nishizawa, Masatoyo

doi:10.1002/adhm.202201627

Cited by 8 publications

(8 citation statements)

References 58 publications

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“…The extremely thin device with 1.0 mm tubes will expand the range of biomedical applications including insertion into narrow in vivo structures as a catheter, and integration with other flexible implanted devices. [32][33][34][35][36] The pictures in Figure 4g are the visual demonstrations of deep insertion into a brain model made of agarose and integration with a hydrogel-based subdural electrode. [34] The totally organic format of the present hydrogel-based delivery device is compatible with MRI imaging due to the minimum image artifacts of organic materials even in high frequency magnetic fields.…”

Section: Thin Flexible Tubular Device For Local Chemical Deliverymentioning

confidence: 99%

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Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels

Terutsuki,

Miyazawa,

Takagi

et al. 2023

Adv Funct Materials

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Spatiotemporally controlled chemical delivery is crucial for various biomedical engineering applications. Here, a novel concept of electrically controllable delivery utilizing electroosmotic flow (EOF) generated in a combination of anionic and cationic hydrogels (A‐ and C‐hydrogels) is reported. The unique advantages of the A/C‐hydrogel combination are demonstrated utilizing a flexible sheet‐shaped and a thin tubular devices. Since the directions of EOF in the A‐ and C‐hydrogels are opposite to each other, the ionic current for EOF generation flows inside the delivery devices, enabling chemical delivery without accompanying external ionic current that could stimulate target cells and tissues. A thin tubular device, which can be inserted into narrow in vivo structures and be integrated with other flexible devices, exhibits high robustness and repeatability thanks to the flexibility and water retentivity of hydrogels. The EOF devices with A/C‐hydrogels combination show high controllability superior to the pumping with a conventional syringe; the volumetric flow rate is able to be controlled proportionally to the current applied, for example, ≈0.4 µL (mA min)−1 for the tubular device. The developed EOF‐based devices are versatile for delivery of most chemicals regardless of their charge and size, and have great potential for both biomedical researches and therapeutics.

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Section: Thin Flexible Tubular Device For Local Chemical Deliverymentioning

confidence: 99%

“…[34] The totally organic format of the present hydrogel-based delivery device is compatible with MRI imaging due to the minimum image artifacts of organic materials even in high frequency magnetic fields. [34][35][36]…”

Section: Thin Flexible Tubular Device For Local Chemical Deliverymentioning

confidence: 99%

Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels

Terutsuki,

Miyazawa,

Takagi

et al. 2023

Adv Funct Materials

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“…Nonetheless, every substrate material has its own advantages, challenges, and requirements which must be understood in order to select the optimal material for the desired application. Figure 1 illustrates the most common substrate materials employed in implantable electrodes, organized from traditional materials (stiff, high modulus) on the left to tissue-like materials (soft, low modulus) on the right [72][73][74][75][76][77][78][79][80][81][82][83][84][85]. A brief overview of each class and its recent developments are provided below.…”

Section: Bioelectronic Implants: Structural Organization and Material...mentioning

confidence: 99%

Lifetime engineering of bioelectronic implants with mechanically reliable thin film encapsulations

Niemiec,

Kim

2023

Prog. Biomed. Eng.

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While the importance of thin form factor and mechanical tissue biocompatibility has been made clear for next generation bioelectronic implants, material systems meeting these criteria still have not demonstrated sufficient long-term durability. This review provides an update on the materials used in modern bioelectronic implants as substrates and protective encapsulations, with a particular focus on flexible and conformable devices. We review how thin film encapsulations are known to fail due to mechanical stresses and environmental surroundings under processing and operating conditions. This information is then reflected in recommending state-of-the-art encapsulation strategies for designing mechanically reliable thin film bioelectronic interfaces. Finally, we assess the methods used to evaluate novel bioelectronic implant devices and the current state of their longevity based on encapsulation and substrate materials. We also provide insights for future testing to engineer long-lived bioelectronic implants more effectively and to make implantable bioelectronics a viable option for chronic diseases in accordance with each patient’s therapeutical timescale.

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“…[10,11,[25][26][27] Other cuff electrodes are already pre-folded using fabrication-induced stress and have to be manually unfolded during the attachment, where they then wrap themselves around the nerve when released. [28][29][30] The difficulty of this procedure further increases with the reduction of the cuff size. Thus, a manual operation on smaller and more delicate nerves brings along an increased risk of nerve damage.…”

Section: Introductionmentioning

confidence: 99%

4D‐Printed Soft and Stretchable Self‐Folding Cuff Electrodes for Small‐Nerve Interfacing

et al. 2023

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Peripheral nerve interfacing (PNI) has a high clinical potential for treating various diseases, such as obesity or diabetes. However, currently existing electrodes present challenges to the interfacing procedure, which limit their clinical application, in particular, when targeting small peripheral nerves (<200 µm). To improve the electrode handling and implantation, a nerve interface that can fold itself to a cuff around a small nerve, triggered by the body moisture during insertion, is fabricated. This folding is achieved by printing a bilayer of a flexible polyurethane printing resin and a highly swelling sodium acrylate hydrogel using photopolymerization. When immersed in an aqueous liquid, the hydrogel swells and folds the electrode softly around the nerve. Furthermore, the electrodes are robust, can be stretched (>20%), and bent to facilitate the implantation due to the use of soft and stretchable printing resins as substrates and a microcracked gold film as conductive layer. The straightforward implantation and extraction of the electrode as well as stimulation and recording capabilities on a small peripheral nerve in vivo are demonstrated. It is believed that such simple and robust to use self‐folding electrodes will pave the way for bringing PNI to a broader clinical application.

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Totally Organic Hydrogel‐Based Self‐Closing Cuff Electrode for Vagus Nerve Stimulation

Cited by 8 publications

References 58 publications

Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels

Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels

Lifetime engineering of bioelectronic implants with mechanically reliable thin film encapsulations

4D‐Printed Soft and Stretchable Self‐Folding Cuff Electrodes for Small‐Nerve Interfacing

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