Totarol, totaradiol and ferruginol: three diterpenes from Thuja plicata (Cupressaceae)

Sharp, Hazel; Latif, Zahid; Bartholomew, Barbara; Bright, Colin; Jones, Phil; Sarker, Satyajit D.; Nash, Robert J.

doi:10.1016/s0305-1978(00)00047-8

Cited by 19 publications

(19 citation statements)

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“…This is, however, the first report of its isolation from the roots and the first report of its antimycobacterial activity. Totarol has previously been isolated from Juniperus procera and other plants within the Cuppressaceae family (Constantine et al, 2001;Iwamoto et al, 2001;Muhammad et al, 1995;Sharp et al, 2001). It has recently been detected in some commercial gin samples aromatised with Juniperus communis berries (Vichi et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae)

Gordien

Gray

Franzblau

et al. 2009

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 99%

Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae)

Gordien

Gray

Franzblau

et al. 2009

Journal of Ethnopharmacology

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“…Ferruginol is an abietane diterpene occurring in plants belonging to the families Podocarpaceae (Cambie et al 1984), Cupressaceae (Sharp et al 2001), Lamiaceae (Ulubelen & Topcu 1992) and Verbenaceae (Ono et al 1999) among others. Recently, it was reported that ferruginol displayed gastroprotective activity against gastric damage induced by HCl/ethanol in mice (Rodríguez et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective activity of ferruginol in mice and rats: effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls

Areche

Theoduloz

Yáñez

et al. 2008

Journal of Pharmacy and Pharmacology

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The gastroprotective mechanism of the natural diterpene ferruginol was assessed in mice and rats. The involvement of gastric prostaglandins (PGE(2)), reduced glutathione, nitric oxide or capsaicin receptors was evaluated in mice either treated or untreated with indometacin, N-ethylmaleimide (NEM), N-nitro-L-arginine methyl ester (L-NAME) or ruthenium red, respectively, and then orally treated with ferruginol or vehicle. Gastric lesions were induced by oral administration of ethanol. The effects of ferruginol on the parameters of gastric secretion were assessed in pylorus-ligated rats. Gastric PGE(2) content was determined in rats treated with ferruginol and/or indometacin. The reduction of gastric glutathione (GSH) content was determined in rats treated with ethanol after oral administration of ferruginol, lansoprazole or vehicle. Finally, the acute oral toxicity was assessed in mice. Indometacin reversed the gastroprotective effect of ferruginol (25 mg kg(-1)) but not NEM, ruthenium red or L-NAME. The diterpene (25 mg kg(-1)) increased the gastric juice volume and its pH value, and reduced the titrable acidity but was devoid of effect on the gastric mucus content. Ferruginol (25, 50 mg kg(-1)) increased gastric PGE(2) content in a dose-dependent manner and prevented the reduction in GSH observed due to ethanol-induced gastric lesions in rats. Single oral doses up to 3 g kg(-1) ferruginol did not elicit mortality or acute toxic effects in mice. Our results showed that ferruginol acted as a gastroprotective agent stimulating the gastric PGE(2) synthesis, reducing the gastric acid output and improving the antioxidant capacity of the gastric mucosa by maintaining the GSH levels.

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“…Ferruginol is an abietane diterpene occurring in plants belonging to the Podocarpaceae (Cambie et al, 1984), Cupressaceae (Sharp et al, 2001), Lamiaceae (Ulubelen and Topcu, 1992) and Verbenaceae (Ono et al, 1999) families among others.…”

Section: Introductionmentioning

confidence: 99%