Tough and biocompatible hybrid networks prepared from methacrylated poly(trimethylene carbonate) (PTMC) and methacrylated gelatin

Jia, Liang; Grijpma, Dirk W.; Poot, Andreas A.

doi:10.1016/j.eurpolymj.2019.109420

Cited by 21 publications

(16 citation statements)

References 31 publications

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“…While the lysine and hydroxylysine typically represent 5% of the gelatin amino acid composition, the glutamic and aspartic acid are three times more highly represented in gelatin (16%) [35]. Also, during the methacrylation reaction of gelatin, a proportion of the amine and hydroxyl groups are functionalized, with the amine groups reacting preferentially [33,78,81]. As a result, the proportion of free amine side groups is decreased by around 80% (corresponding to the degree of functionalization).…”

Section: Impact Of the Ph Of The Swelling Mediamentioning

confidence: 99%

Deciphering the Molecular Mechanism of Water Interaction with Gelatin Methacryloyl Hydrogels: Role of Ionic Strength, pH, Drug Loading and Hydrogel Network Characteristics

et al. 2021

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Water plays a primary role in the functionality of biomedical polymers such as hydrogels. The state of water, defined as bound, intermediate, or free, and its molecular organization within hydrogels is an important factor governing biocompatibility and hemocompatibility. Here, we present a systematic study of water states in gelatin methacryloyl (GelMA) hydrogels designed for drug delivery and tissue engineering applications. We demonstrate that increasing ionic strength of the swelling media correlated with the proportion of non-freezable bound water. We attribute this to the capability of ions to create ion–dipole bonds with both the polymer and water, thereby reinforcing the first layer of polymer hydration. Both pH and ionic strength impacted the mesh size, having potential implications for drug delivery applications. The mechanical properties of GelMA hydrogels were largely unaffected by variations in ionic strength or pH. Loading of cefazolin, a small polar antibiotic molecule, led to a dose-dependent increase of non-freezable bound water, attributed to the drug’s capacity to form hydrogen bonds with water, which helped recruit water molecules in the hydrogels’ first hydration layer. This work enables a deeper understanding of water states and molecular arrangement at the hydrogel–polymer interface and how environmental cues influence them.

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Section: Impact Of the Ph Of The Swelling Mediamentioning

confidence: 99%

Deciphering the Molecular Mechanism of Water Interaction with Gelatin Methacryloyl Hydrogels: Role of Ionic Strength, pH, Drug Loading and Hydrogel Network Characteristics

et al. 2021

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“…UV irradiation is often considered as a chemical crosslinking method, as it is achieved through chemical photo initiators (either created in-situ or introduced from an exogenous source) that initiate the catalytic process of the formation of the covalent bonds between the polymer chains [ 46 ]. Among different exogenous photo initiators (also referred to as crosslinker), the Irgacure 2959 (1-[4-(2-hydroxyethoxy)phenyl]-2-hydroxy-2-methyl-1-propan-1-one) seems to be the most popular one [ 54 , 55 ]. Unfortunately, as many others active chemical compounds, it can also be considered to be an undesirable additive.…”

Section: The Crosslinking Strategiesmentioning

confidence: 99%

Advances in Fabricating the Electrospun Biopolymer-Based Biomaterials

Wilk

Benko

2021

JFB

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Biopolymers formed into a fibrous morphology through electrospinning are of increasing interest in the field of biomedicine due to their intrinsic biocompatibility and biodegradability and their ability to be biomimetic to various fibrous structures present in animal tissues. However, their mechanical properties are often unsatisfactory and their processing may be troublesome. Thus, extensive research interest is focused on improving these qualities. This review article presents the selection of the recent advances in techniques aimed to improve the electrospinnability of various biopolymers (polysaccharides, polynucleotides, peptides, and phospholipids). The electrospinning of single materials, and the variety of co-polymers, with and without additives, is covered. Additionally, various crosslinking strategies are presented. Examples of cytocompatibility, biocompatibility, and antimicrobial properties are analyzed. Special attention is given to whey protein isolate as an example of a novel, promising, green material with good potential in the field of biomedicine. This review ends with a brief summary and outlook for the biomedical applicability of electrospinnable biopolymers.

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“…Even though these modifications may lead to better-performing materials for applications in tissue engineering or drug delivery systems, synthesizing hybrid materials can be very challenging, especially when different fabrication techniques must be employed. Therefore, a balance between the complexity of the production and fabrication processes and the benefits presented by the hybrid materials must be maintained [69,70].…”

Section: Bio-synthetic Hybrid Polymersmentioning

confidence: 99%

Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems

et al. 2020

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Nowadays, tissue engineering is described as an interdisciplinary field that combines engineering principles and life sciences to generate implantable devices to repair, restore and/or improve functions of injured tissues. Such devices are designed to induce the interaction and integration of tissue and cells within the implantable matrices and are manufactured to meet the appropriate physical, mechanical and physiological local demands. Biodegradable constructs based on polymeric fibers are desirable for tissue engineering due to their large surface area, interconnectivity, open pore structure, and controlled mechanical strength. Additionally, biodegradable constructs are also very sought-out for biomolecule delivery systems with a target-directed action. In the present review, we explore the properties of some of the most common biodegradable polymers used in tissue engineering applications and biomolecule delivery systems and highlight their most important uses.

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Tough and biocompatible hybrid networks prepared from methacrylated poly(trimethylene carbonate) (PTMC) and methacrylated gelatin

Cited by 21 publications

References 31 publications

Deciphering the Molecular Mechanism of Water Interaction with Gelatin Methacryloyl Hydrogels: Role of Ionic Strength, pH, Drug Loading and Hydrogel Network Characteristics

Deciphering the Molecular Mechanism of Water Interaction with Gelatin Methacryloyl Hydrogels: Role of Ionic Strength, pH, Drug Loading and Hydrogel Network Characteristics

Advances in Fabricating the Electrospun Biopolymer-Based Biomaterials

Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems

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