Toughening of Bioceramic Composites for Bone Regeneration

Abbas, Zahid; Dapporto, Massimiliano; Tampieri, Anna; Sprio, Simone

doi:10.3390/jcs5100259

Cited by 28 publications

(8 citation statements)

References 275 publications

(289 reference statements)

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“…In most cases, it is necessary to increase the bending strength, reduce elasticity, and avoid material failure. As a positive effect, it was reported that the fracture toughness and flexural strength of bioceramics increased in wet environments [ 85 ]. To overcome the above limitation, the usage of bioceramic coatings and the development of nanocomposite ceramics should be considered as appropriate approaches [ 86 , 87 ].…”

Section: Ceramic Materials For Biomedical Applicationsmentioning

confidence: 99%

Ceramic Materials for Biomedical Applications: An Overview on Properties and Fabrication Processes

Vaiani

Boccaccio

Uva

et al. 2023

JFB

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A growing interest in creating advanced biomaterials with specific physical and chemical properties is currently being observed. These high-standard materials must be capable to integrate into biological environments such as the oral cavity or other anatomical regions in the human body. Given these requirements, ceramic biomaterials offer a feasible solution in terms of mechanical strength, biological functionality, and biocompatibility. In this review, the fundamental physical, chemical, and mechanical properties of the main ceramic biomaterials and ceramic nanocomposites are drawn, along with some primary related applications in biomedical fields, such as orthopedics, dentistry, and regenerative medicine. Furthermore, an in-depth focus on bone-tissue engineering and biomimetic ceramic scaffold design and fabrication is presented.

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Section: Ceramic Materials For Biomedical Applicationsmentioning

confidence: 99%

Ceramic Materials for Biomedical Applications: An Overview on Properties and Fabrication Processes

Vaiani

Boccaccio

Uva

et al. 2023

JFB

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“…Bioceramic is an important biocompatible ceramic material with excellent bioactivity, chemical stability, thermal resistance, and tissue-like mechanical characteristics. Bioceramics have been used as a nanoporous scaffold material to repair and reconstruct damaged tissues, fill bone defects, and deliver drug molecules [ 139 , 140 , 141 , 142 ]. Bioceramics, such as calcium phosphate and hydroxyapatite, can be extracted from natural waste materials (eggshell, bovine bone, fish bone, and seashells), which are widely geographically available at low cost.…”

Section: Sustainable Nanomaterials For Biomedical Applicationsmentioning

confidence: 99%

Sustainable Nanomaterials for Biomedical Applications

et al. 2023

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Significant progress in nanotechnology has enormously contributed to the design and development of innovative products that have transformed societal challenges related to energy, information technology, the environment, and health. A large portion of the nanomaterials developed for such applications is currently highly dependent on energy-intensive manufacturing processes and non-renewable resources. In addition, there is a considerable lag between the rapid growth in the innovation/discovery of such unsustainable nanomaterials and their effects on the environment, human health, and climate in the long term. Therefore, there is an urgent need to design nanomaterials sustainably using renewable and natural resources with minimal impact on society. Integrating sustainability with nanotechnology can support the manufacturing of sustainable nanomaterials with optimized performance. This short review discusses challenges and a framework for designing high-performance sustainable nanomaterials. We briefly summarize the recent advances in producing sustainable nanomaterials from sustainable and natural resources and their use for various biomedical applications such as biosensing, bioimaging, drug delivery, and tissue engineering. Additionally, we provide future perspectives into the design guidelines for fabricating high-performance sustainable nanomaterials for medical applications.

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“…The crucial factors for scaffold materials are their toughness and porosity [215]. It is also important to study and determine how the daily activities of humans affect the fatigue life of porous scaffold implants [216].…”

Section: Future Perspectives and Possible Limitationsmentioning

confidence: 99%

Calcium Phosphate Loaded Biopolymer Composites—A Comprehensive Review on the Most Recent Progress and Promising Trends

Furkó

Balázsi

2023

Coatings

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Biocompatible ceramics are extremely important in bioengineering, and very useful in many biomedical or orthopedic applications because of their positive interactions with human tissues. There have been enormous efforts to develop bioceramic particles that cost-effectively meet high standards of quality. Among the numerous bioceramics, calcium phosphates are the most suitable since the main inorganic compound in human bones is hydroxyapatite, a specific phase of the calcium phosphates (CaPs). The CaPs can be applied as bone substitutes, types of cement, drug carriers, implants, or coatings. In addition, bioresorbable bioceramics have great potential in tissue engineering in their use as a scaffold that can advance the healing process of bones during the normal tissue repair process. On the other hand, the main disadvantages of bioceramics are their brittleness and poor mechanical properties. The newest advancement in CaPs doping with active biomolecules such as Mg, Zn, Sr, and others. Another set of similarly important materials in bioengineering are biopolymers. These include natural polymers such as collagen, cellulose acetate, gelatin, chitosan, and synthetic polymers, for example, polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), and polycaprolactone (PCL). Various types of polymer have unique properties that make them useful in different fields. The combination of CaP particles with different biopolymers gives rise to new opportunities for application, since their properties can be changed and adjusted to the given requirements. This review offers an insight into the most up-to-date advancements in the preparation and evaluation of different calcium phosphate–biopolymer composites, highlighting their application possibilities, which largely depend on the chemical and physical characteristics of CaPs and the applied polymer materials. Overall, these composites can be considered advanced materials in many important biomedical fields, with potential to improve the quality of healthcare and to assist in providing better outcomes as scaffolds in bone healing or in the integration of implants in orthopedic surgeries.

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Toughening of Bioceramic Composites for Bone Regeneration

Cited by 28 publications

References 275 publications

Ceramic Materials for Biomedical Applications: An Overview on Properties and Fabrication Processes

Ceramic Materials for Biomedical Applications: An Overview on Properties and Fabrication Processes

Sustainable Nanomaterials for Biomedical Applications

Calcium Phosphate Loaded Biopolymer Composites—A Comprehensive Review on the Most Recent Progress and Promising Trends

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