Tourette syndrome: an analysis of 200 pediatric and adolescent cases

Erenberg, Gerald; Rp, Cruse; Ad, Rothner

doi:10.3949/ccjm.53.2.127

Cited by 102 publications

(57 citation statements)

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“…Our study confirms previous observations that coprolalia is relatively infrequent in younger patients (15). A previous study of a pediatric population showed that 8% of patients exhibited coprolalia (14). Kurlan et al (16), in a report describing a large Mennonite kindred, identified 29 subjects with GTS or chronic motor tics.…”

Section: Discussionmentioning

confidence: 99%

Coprolalia in younger patients with Gilles de la tourette syndrome

Goldenberg¹,

Brown²,

Weiner³

1994

Movement Disorders

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The objective of this study was to determine the frequency of coprolalia in younger patients with Gilles de la Tourette syndrome (GTS). Coprolalia, which is the least understood and perhaps most unusual symptom of GTS, is reported to occur in 4-60% of all patients with GTS. Most reports indicate a prevalence > 30%. The widely varying prevalence figures for coprolalia may reflect cultural differences, severity of disease, and the age of the population surveyed. This study is a chart review of 112 patients seen in a pediatric neurology clinic in South Florida who met the Diagnostic and Statistical Manual of Mental Disorder (3rd ed., revised) criteria for GTS. Only 8% of the patients in the study exhibited coprolalia. This unusually low frequency of coprolalia suggests that coprolalia may be rarer than previously believed in younger patients. It may also better reflect the frequency of coprolalia in a community-based pediatric neurology practice.

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Section: Discussionmentioning

confidence: 99%

Coprolalia in younger patients with Gilles de la tourette syndrome

Goldenberg¹,

Brown²,

Weiner³

1994

Movement Disorders

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“…8 Symptoms of Tourette Syndrome range from mild to severe, with most cases showing mild or moderate symptoms. [8][9][10][11] In community and clinically ascertained samples, over half of children with Tourette Syndrome have a co-occurring mental, emotional, or behavioral condition 12 most commonly attention-deficit/hyperactivity disorder and obsessive-compulsive disorder. 4,8,[13][14][15] These co-occurring conditions often contribute to the adverse impact of Tourette Syndrome on educational outcomes, family stress, social relationships and health care needs.…”

Section: Introductionmentioning

confidence: 99%

Health Care Needs of Children With Tourette Syndrome

et al. 2012

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To document the impact of Tourette syndrome on the health care needs of children and access to health care among youth with Tourette syndrome, parent-reported data from the 2007-2008 National Survey of Children's Health were analyzed. Children with Tourette syndrome had more co-occurring mental disorders than children with asthma or children without Tourette syndrome or asthma and had health care needs that were equal to or greater than children with asthma (no Tourette syndrome) or children with neither asthma nor Tourette syndrome. Health care needs were greatest among children with Tourette syndrome and co-occurring mental disorders, and these children were least likely to receive effective care coordination. Addressing co-occurring conditions may improve the health and well-being of children with Tourette syndrome. Strategies such as integration of behavioral health and primary care may be needed to improve care coordination.

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“…The diagnosis depends on the presence of motor and vocal tics that have their onset in childhood and are present almost daily for at least 1 year [Diagnostic and Statistical Manual of Mental Disorders, 1980,19871. There is a wide range of associated behaviors including attention deficit disorder with or without hyperactivity, obsessive-compulsive behaviors, conduct disorder, learning disabilities, stuttering, sleep disorders, inappropriate sexual behaviors, and others [Burd and Kerbeshian, 1984;Burd et al, 1987;Comings, 1987Comings, ,1989aComings, , 1990,1985, 1987aEldridge et al, 1977;Erenberg et al, 1986;Jagger et al, 1982;Burd, 1987, 1989;Ludlow et al, 1982;Mendelson et al, 1980;Nee et al, Individual Pedigrees Our first suspicion that some TS patients might be homozygous came from some individuals whose mother and father had either TS or tics and whose symptoms were particularly severe.…”

Section: Introductionmentioning

confidence: 99%

Hypothesis: Homozygosity in tourette syndrome

Comings

Comings²,

Knell

1989

Am. J. Med. Genet.

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We review evidence suggesting that many individuals with Tourette syndrome (TS) may be homozygous for a "Tourette syndrome" gene. This is based on experience with pedigrees on 1,200 TS families, comparison of the occurrence of tics or associated behaviors such as obsessive-compulsive behavior, panic attacks, attention deficit hyperactivity disorder, and/or severe alcohol or drug abuse, on both the maternal and paternal side in 170 TS families compared to control families, biochemical studies of blood serotonin and tryptophan levels, and other evidence. These observations suggest the inheritance in TS may be best described as semi-dominant, semi-recessive. Some of the implications of this proposal are discussed.

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Tourette syndrome: an analysis of 200 pediatric and adolescent cases

Cited by 102 publications

References 0 publications

Coprolalia in younger patients with Gilles de la tourette syndrome

Coprolalia in younger patients with Gilles de la tourette syndrome

Health Care Needs of Children With Tourette Syndrome

Hypothesis: Homozygosity in tourette syndrome

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