The aim of our research was to study the microclimate's influence on some clinical and physiological parameters of calves in the conditions of livestock complexes of the Republic of Dagestan. Research methods: veterinary, zootechnical, logical, systemic. The results of the study of calf pen microclimate parameters showed the range of fluctuations: temperature 6,5-22,5 0 C, humidity 74.2 -98.1%, air velocity 0.25- 0.40m/s, carbon dioxide concentration 0.4 -0.2% and ammonia 2-6 mg/m3. The study results of the clinical and physiological calves’ state showed changes in body temperature from 38.0 to 39.3 0C, pulse rate from 65 to 71 beats per minute, respiratory frequency movements from 22 to 26 per minute. The results of hematological studies has shown that the studied indicators had a range of fluctuations: hemoglobin 8.6 - 9.4 g%, erythrocytes 7.1-7,9, leukocytes 7.2-8.9 th./mm3. Conclusions. The study results of the calf pen microclimate showed that it complied with zoohygienic norms. The relative humidity and air velocity indicators exceeded the permissible zoohygienic standards. Indicators of calves’ physiological condition corresponded to the norms of a healthy animal. Hematological and biochemical blood indicators of calves were within the physiological norm.