Toward a better understanding of folate metabolism in health and disease

Zheng, Yuxiang; Cantley, Lewis C.

doi:10.1084/jem.20181965

Cited by 157 publications

(130 citation statements)

References 164 publications

(205 reference statements)

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“…Biotin also regulates important functions such as cell signaling and mucosal immune responses [55]. Through the upregulation of onecarbon metabolism, neurotransmitter biosynthesis (dopamine and serotonin) and oxidative stress reduction [56,57], greater production of vitamin B 6 and folate (vitamin B 9 ) could become key cofactors for regulation of cellular metabolism [58,59]. Together, data suggest that induction of B vitamins metabolism in the microbiome of M-eff heifers might have contributed to increasing the supply of B vitamins during the preweaning period.…”

Section: Vitamin Supplymentioning

confidence: 99%

Residual feed intake divergence during the preweaning period is associated with unique hindgut microbiome and metabolome profiles in neonatal Holstein heifer calves

Elolimy

Alharthi

Zeineldin

et al. 2020

J Animal Sci Biotechnol

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Background: Recent studies underscored that divergence in residual feed intake (RFI) in mature beef and dairy cattle is associated with changes in ruminal microbiome and metabolome profiles which may contribute, at least in part, to better feed efficiency. Because the rumen in neonatal calves during the preweaning period is underdeveloped until close to weaning, they rely on hindgut microbial fermentation to breakdown undigested diet components. This leads to production of key metabolites such as volatile fatty acids (VFA), amino acids, and vitamins that could potentially be absorbed in the hind-gut and help drive growth and development. Whether RFI divergence in neonatal calves is associated with changes in hindgut microbial communities and metabolites is largely unknown. Therefore, the objective of the current study was to determine differences in hindgut microbiome and metabolome in neonatal Holstein heifer calves retrospectively-grouped based on feed efficiency as mostefficient (M-eff) or least-efficient (L-eff) calves using RFI divergence during the preweaning period. Methods: Twenty-six Holstein heifer calves received 3.8 L of first-milking colostrum from their respective dams within 6 h after birth. Calves were housed in individual outdoor hutches bedded with straw, fed twice daily with a milk replacer, and had ad libitum access to a starter grain mix from birth to weaning at 42 d of age. Calves were classified into M-eff [n = 13; RFI coefficient = − 5.72 ± 0.94 kg DMI (milk replacer + starter grain)/d] and L-eff [n = 13; RFI coefficient = 5.61 ± 0.94 kg DMI (milk replacer + starter grain)/d] based on a linear regression model including the combined starter grain mix and milk replacer DMI, average daily gain (ADG), and metabolic body weight (MBW). A deep sterile rectal swab exposed only to the rectum was collected immediately at birth before colostrum feeding (i.e., d 0), and fecal samples at d 14, 28, and 42 (prior to weaning) for microbiome and untargeted metabolome analyses using 16S rRNA gene sequencing and LC-MS. Microbiome data were analyzed with the QIIME 2 platform and metabolome data with the MetaboAnalyst 4.0 pipeline.

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Section: Vitamin Supplymentioning

confidence: 99%

Residual feed intake divergence during the preweaning period is associated with unique hindgut microbiome and metabolome profiles in neonatal Holstein heifer calves

Elolimy

Alharthi

Zeineldin

et al. 2020

J Animal Sci Biotechnol

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“…1)]. Among those, only two compounds are fairly stable (Gregory, 2012; Zheng and Cantley, 2019), namely 5‐methyl‐tetrahydrofolate (CH 3 ‐ N 5 ‐H 4 F) and 5‐formyl‐tetrahydrofolate (CHO‐ N 5 ‐H 4 F). The latter seems to be a dead‐end store product that does not appear to be directly involved in a significant number of biochemical reactions, except for its isomerization into the metabolically reactive form, 10‐formyl‐tetrahydrofolate (CHO‐ N 10 ‐H 4 F).…”

Section: Methionine As the Main Product Of Folate Metabolismmentioning

confidence: 99%

One‐carbon metabolism, folate, zinc and translation

Danchin

Sekowska

You

2020

Microbial Biotechnology

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The translation process, central to life, is tightly connected to the one-carbon (1-C) metabolism via a plethora of macromolecule modifications and specific effectors. Using manual genome annotations and putting together a variety of experimental studies, we explore here the possible reasons of this critical interaction, likely to have originated during the earliest steps of the birth of the first cells.Methionine, S-adenosylmethionine and tetrahydrofolate dominate this interaction. Yet, 1-C metabolism is unlikely to be a simple frozen accident of primaeval conditions. Reactive 1-C species (ROCS) are buffered by the translation machinery in a way tightly associated with the metabolism of iron-sulfur clusters, zinc and potassium availability, possibly coupling carbon metabolism to nitrogen metabolism. In this process, the highly modified position 34 of tRNA molecules plays a critical role. Overall, this metabolic integration may serve both as a protection against the deleterious formation of excess carbon under various growth transitions or environmental unbalanced conditions and as a regulator of zinc homeostasis, while regulating input of prosthetic groups into nascent proteins. This knowledge should be taken into account in metabolic engineering.

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“…Vitamin B6 acts as coenzyme in various distinct enzymatic activities, such as amino acid, carbohydrate and lipid metabolism (di Salvo, Contestabile, & Safo, ). Folate participates in multiplex biochemical processes by regulating purine and thymidine monophosphate (dTMP) biosynthesis, methionine regeneration and mitochondrial protein translation (Zheng & Cantley, ).…”

Section: Discussionmentioning

confidence: 99%

A global view of hepatopancreas and intestinal reveals the potential influencing mechanism of aflatoxin B1 on nutrition and metabolism inLitopenaeus vannamei

et al. 2019

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The present study was to determine the time‐dependent alterations in growth performance, histomorphology, digestive enzymes activities and the genes expression related to target of rapamycin (TOR) signalling pathway involved in hepatopancreas and intestine of Litopenaeus vannamei at 3, 6, 12, 18, 24 and 30 days after Aflatoxin B1 (AFB1) challenge. The results manifested that AFB1 could induce a significant decrease in growth performance and visible variations of the hepatopancreas and intestine structures in shrimp. Meanwhile, the digestive enzymes activities and genes expression level were significantly lower in the experimental group than in the control group and showed a time‐dependent decrease (p < 0.05). The expression levels of tor and s6k were significantly higher in the experimental group than in the control group from days 6 to 24 and showed a tendency to increase first and then decrease as a whole (p < 0.05). Meanwhile, we analysed candidate pathways involved in hepatopancreas and intestine of shrimp in metabolic response to AFB1. The mainly disturbed pathways related to metabolism in hepatopancreas were involved in pyrimidine, glycosylphosphatidylinositol, glycosaminoglycan, vitamin and amino acid biosynthesis and metabolism, while the mainly disturbed metabolic pathways in intestine were glycosaminoglycan, vitamin and amino acid biosynthesis and metabolism.

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Toward a better understanding of folate metabolism in health and disease

Cited by 157 publications

References 164 publications

Residual feed intake divergence during the preweaning period is associated with unique hindgut microbiome and metabolome profiles in neonatal Holstein heifer calves

Residual feed intake divergence during the preweaning period is associated with unique hindgut microbiome and metabolome profiles in neonatal Holstein heifer calves

One‐carbon metabolism, folate, zinc and translation

A global view of hepatopancreas and intestinal reveals the potential influencing mechanism of aflatoxin B1 on nutrition and metabolism inLitopenaeus vannamei

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