Toward a Better Understanding of Sinonasal Mucosal Melanoma: Clinical Review of 23 Cases

Cheng, Yen-Fu; Lai, Chung K.; Ho, Ching‐Yin; Shu, Ching‐Fong; Lin, Ching‐Yi

doi:10.1016/s1726-4901(09)70296-5

Cited by 67 publications

(44 citation statements)

References 23 publications

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“…[ Table 1] There are conflicting reports regarding the incidence of sinonasal mucosal melanoma in males and females. 6,8,26,[40][41][42][43] The male/female ratio of our patients was 8, which is consistent with the study by Richtig et al 6 However, in the literature review, by analyzing the data of the reported series, the mean male/female ratio of 843 patients was 1.07 and we did not find significant differences. [ Table 1]…”

Section: Discussionsupporting

confidence: 91%

Melanoma primário de mucosa do trato nasossinusal: relato de 18 pacientes e análise de 1077 pacientes na literatura

Khademi¹,

Bahranifard²,

Nasrollahi³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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The present study aimed at reporting on the characteristics, prognostic factors and treatment outcomes of 18 cases of nasosinusal mucosa melanoma, and do a literature review on the subject.Methods: between 1995 and 2005, 18 patients consecutively diagnosed with nasosinusal mucosa melanoma were managed in our institution. We reviewed the literature in PubMed and Scopus in order to find the main series from studies associated with this topic. We found a total of 35 series, involving 1,077 patients with nasosinusal mucosa melanoma.Results: we found 16 men and 2 women, with age at presentation between 51 and 80 years (median of 58 years). All these patients were submitted to surgical excision followed by radiotherapy with or without chemotherapy. The survival median was 15 months, and the 5-year general survival had a percentage value of 23%. Considering our univariate analysis: tumor staging and complete remission after initial treatment were deemed relevant prognostic factors. Nonetheless, considering the multivariate analysis, only disease stage was statistically significant. Conclusion:nasosinusal melanoma is a rare and aggressive tumor, with high loco-regional and distant failure rates, and poor treatment outcomes. Notwithstanding, in a literature review we found significant improvements considering the 5-year survival for recent series when compared to previously reported ones. Braz J Otorhinolaryngol. 2011;77(1):58-64. ORIGINAL ARTICLE

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Section: Discussionsupporting

confidence: 91%

Melanoma primário de mucosa do trato nasossinusal: relato de 18 pacientes e análise de 1077 pacientes na literatura

Khademi¹,

Bahranifard²,

Nasrollahi³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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“…However, there is no universally accepted provision for paranasal sinus melanoma staging within the TNM system according to Cheng and Lai's 2007 article "Towards a Better Understanding of Sino Nasal Mucosal Melanoma" [6] . Most clinicians use a simplified three-stage system: stage Ⅰ for localized disease, stage Ⅱ for lymph node metastases, and stage Ⅲ for distant metastasis [1] .…”

Section: Stagingmentioning

confidence: 99%

“…Even though traditionally these tumors were known to be radioresistant, some investigations suggest the use of radiation therapy after resection of mucosal melanoma [1] . Therefore, complete surgical removal of tumor and postoperative radiation therapy is the standard of care for resectable lesions [5,6] . Clinical data has proven that combining chemotherapy (either intraarterial or intravenous) along with radiation therapy may improve local control of paranasal sinus tumors.…”

Section: Treatmentmentioning

confidence: 99%

“…The diagnostic tools to identify the type and extent of tumor invasion include a thorough physical examination, CT scan, MRI, and biopsy, and even then diagnosis remains exceedingly difficult. Unfortunately, the prognosis of mucosal paranasal melanoma remains poor with a mean 5-year overall survival rate of only 15.7% [6,10] . The key and critical issue in dealing with malignant mucosal melanoma of paranasal sinuses is early diagnosis in order to comply with the primary modality of treatment, which is surgical excision and radiation therapy with adequate follow-up.…”

Section: Treatmentmentioning

confidence: 99%

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Malignant mucosal melanoma of the paranasal sinuses: Two case presentations

Gasparyan

Amiri²,

Safdieh³

et al. 2011

WJCO

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Primary mucosal melanoma of the paranasal sinuses is a rare tumor of the head and neck which can be a devastating disease. Cancers arising in the sinonasal cavity are extremely rare, with a poor survival rate. There is inherent difficulty in diagnosing these lesions due to their complex anatomic locations and symptoms which are often confused with more common benign processes. The primary treatment of this rare disease process is resection, except in advanced stages where surgical resection is not an option. Diagnostic accuracy in consideration of size, location, and presence of metastatic disease of these malignant tumors tailors individual patients to different management in order to achieve the longest possible survival.

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“…Так, у японцев частота встречаемости МСО на-много выше (8 % всех меланом) по сравнению с пока-зателями у пациентов европеоидной расы (1 %) [21][22][23][24]. Более того, 7,5 % всех меланом у японцев развиваются в полости рта (1 % у пациентов европеоидной расы) [25,26].…”

Section: этиопатогенезunclassified

Clinical features of the head and neck mucosal melanoma. А review

Игнатова¹,

Мудунов²,

Подвязников³

2016

Opuholi golovy šei

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ВведениеПервичные меланомы слизистых оболочек (МСО) были описаны в 1859 г. К. О. Вебером и с тех пор рас-сматриваются как редко встречающиеся опухоли [1,2]. Они чаще всего локализуются в области верхних дыха-тельных и пищеварительных путей, а именно -в око-лоносовых пазухах и полости рта [3][4][5].Первичные МСО головы и шеи (МСОГШ) состав-ляют около 0,7-3,8 % всех меланом и локализуются (в убывающем порядке по частоте встречаемости) в околоносовых пазухах, полости рта, глотке, гортани и верхней трети пищевода [2,[4][5][6]. МСОГШ ассоции-руются с плохим клиническим исходом и обладают высоким метастатическим потенциалом, 5-летняя без-рецидивная выживаемость составляет от 0 до 20 % [8][9][10][11].Несмотря на единый гистогенез, МСОГШ имеют ряд особенностей в силу специфического анатомо-топографического расположения очага и клиническо-го прогноза заболевания. Локализация на слизистой оболочке значительно затрудняет обнаружение обра-зования самими пациентами, что приводит к несвоев-

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Toward a Better Understanding of Sinonasal Mucosal Melanoma: Clinical Review of 23 Cases

Abstract: In our experience, primary sinonasal mucosa melanoma is prone to spread from the site of origin. The major obstacle in improving overall survival is achieving systemic control.

Cited by 67 publications

References 23 publications

Melanoma primário de mucosa do trato nasossinusal: relato de 18 pacientes e análise de 1077 pacientes na literatura

Melanoma primário de mucosa do trato nasossinusal: relato de 18 pacientes e análise de 1077 pacientes na literatura

Malignant mucosal melanoma of the paranasal sinuses: Two case presentations

Clinical features of the head and neck mucosal melanoma. А review

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