Toward a Neuroimaging Treatment Selection Biomarker for Major Depressive Disorder

McGrath, Callie L.; Kelley, Mary E.; Holtzheimer, Paul E.; Dunlop, Boadie W.; Craighead, W. Edward; Franco, Alexandre R.; Craddock, R. Cameron; Mayberg, Helen S.

doi:10.1001/jamapsychiatry.2013.143

Cited by 507 publications

(353 citation statements)

References 73 publications

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“…Second, we did not correct for potential effects of psychotherapy, which might be a limiting factor of the current study design. However, previous evidence demonstrated differential effects of remission to psychotherapy in the anterior insula and the subgenual cingulate [57,58], while no effects on the thalamus were demonstrated. The potential influence in our sample, given low numbers of current psychotherapy, might be small, but future studies should control for psychotherapy.…”

Section: Discussionmentioning

confidence: 78%

The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI

et al. 2018

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Functional magnetic resonance imaging (fMRI) successfully disentangled neuronal pathophysiology of major depression (MD), but only a few fMRI studies have investigated correlates and predictors of remission. Moreover, most studies have used clinical outcome parameters from two time points, which do not optimally depict differential response times. Therefore, we aimed to detect neuronal correlates of response and remission in an antidepressant treatment study with 7 T fMRI, potentially harnessing advances in detection power and spatial specificity. Moreover, we modeled outcome parameters from multiple study visits during a 12-week antidepressant fMRI study in 26 acute (aMD) patients compared to 36 stable remitted (rMD) patients and 33 healthy control subjects (HC). During an electrical painful stimulation task, significantly higher baseline activity in aMD compared to HC and rMD in the medial thalamic nuclei of the pulvinar was detected (p = 0.004, FWE-corrected), which was reduced by treatment. Moreover, clinical response followed a sigmoid function with a plateau phase in the beginning, a rapid decline and a further plateau at treatment end. By modeling the dynamic speed of response with fMRI-data, perigenual anterior cingulate activity after treatment was significantly associated with antidepressant response (p < 0.001, FWE-corrected). Temporoparietal junction (TPJ) baseline activity significantly predicted non-remission after 2 antidepressant trials (p = 0.005, FWE-corrected). The results underline the importance of the medial thalamus, attention networks in MD and antidepressant treatment. Moreover, by using a sigmoid model, this study provides a novel method to analyze the dynamic nature of response and remission for future trials.

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Section: Discussionmentioning

confidence: 78%

The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI

et al. 2018

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“…In a study 8 published last year, neurologist Helen Mayberg of Emory University in Atlanta, Georgia, and her colleagues used positron emission tomography (PET) to measure glucose metabolism in the brains of 82 adults with depression. They then randomly assigned each participant to receive 12 weeks of treatment with either CBT or a commonly prescribed antidepressant from the selective serotonin reuptake inhibitor class.…”

Section: Tough Questions Tough Answersmentioning

confidence: 99%

Depression: A change of mind

Anthes¹

2014

Nature

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“…One trial selected for MDD patients who had never received antidepressant treatment during their lifetime (N ¼ 98: Dunlop et al, 2012a). The other trial enrolled patients who had prior antidepressant treatment but were medication free for at least 2 weeks before the scanning (N ¼ 36; Dunlop et al, 2012b;McGrath et al, 2013). All participants, including HC, were evaluated for current or past psychiatric disorders using the Structured Clinical Interview for DSM-IV (First et al, 1995) and an interview with a study psychiatrist.…”

Section: Participantsmentioning

confidence: 99%

Reconciling Variable Findings of White Matter Integrity in Major Depressive Disorder

Choi

Holtzheimer

Franco

et al. 2013

Neuropsychopharmacol

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Diffusion tensor imaging (DTI) has been used to evaluate white matter (WM) integrity in major depressive disorder (MDD), with several studies reporting differences between depressed patients and controls. However, these findings are variable and taken from relatively small studies often using suboptimal analytic approaches. The presented DTI study examined WM integrity in large samples of medication-free MDD patients (n ¼ 134) and healthy controls (n ¼ 54) using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) approaches, and rigorous statistical thresholds. Compared with health control subjects, MDD patients show no significant differences in fractional anisotropy, radial diffusivity, mean diffusivity, and axonal diffusivity with either the VBM or the TBSS approach. Our findings suggest that disrupted WM integrity does not have a major role in the neurobiology of MDD in this relatively large study using optimal imaging acquisition and analysis; however, this does not eliminate the possibility that certain patient subgroups show WM disruption associated with depression.

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Toward a Neuroimaging Treatment Selection Biomarker for Major Depressive Disorder

Cited by 507 publications

References 73 publications

The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI

The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI

Depression: A change of mind

Reconciling Variable Findings of White Matter Integrity in Major Depressive Disorder

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