Toward a Reconceptualization of Stem Cells from Cellular Plasticity

Liu, Tao; Chen, Li; Zhao, Zhongjian; Zhang, Shichang

doi:10.15283/ijsc18096

Cited by 4 publications

(1 citation statement)

References 56 publications

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“…Of note, although the transdifferentiation concept is still controversial, especially for in vitro studies, recent studies have demonstrated that adult cell transition can occur spontaneously in vivo under physiological or pathological conditions [44][45][46]. However, evidence of this mechanism in the physiology of age-related bone loss has not yet been proven in vivo.…”

Section: Plos Onementioning

confidence: 99%

Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss

et al. 2021

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Our preliminary findings have lead us to propose bone marrow adipocyte secretions as new contributors to bone loss. Indeed, using a coculture model based on human bone marrow stromal cells, we previously showed that soluble factors secreted by adipocytes induced the conversion of osteoblasts towards an adipocyte-like phenotype. In this study, microarray gene expression profiling showed profound transcriptomic changes in osteoblasts following coculture and confirmed the enrichment of the adipocyte gene signature. Double immunofluorescence microscopic analyses demonstrated the coexpression of adipogenic and osteoblastic specific markers in individual cells, providing evidence for a transdifferentiation event. At the molecular level, this conversion was associated with upregulated expression levels of reprogramming genes and a decrease in the DNA methylation level. In line with these in vitro results, preliminary immunohistochemical analysis of bone sections revealed adipogenic marker expression in osteoblasts from elderly subjects. Altogether, these data suggest that osteoblast transdifferentiation could contribute to decreased bone mass upon ageing.

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Section: Plos Onementioning

confidence: 99%

Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss

et al. 2021

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Magneto‐Electrically Enhanced Intracellular Catalysis of FePt‐FeC Heterostructures for Chemodynamic Therapy

Zhang

Yang

et al. 2021

Advanced Materials

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of diseases. For example, inducing cancer cells from the aggressive and unrestricted growth state to a senescent state can limit their proliferation and reduce their resistance to treatments, [2] which can be realized by intracellular catalytic reduction of β-nicotinamide adenine dinucleotide (NAD + ). [3] However, it remains a challenge to realize highly efficient intracellular catalysis of nanocatalysts in the complex tumor microenvironment.Catalytic reaction is accompanied by electron transfer, and regulating the electronic structure of the catalyst has been an efficient way to improve the catalytic activity. [4] Heterostructures are superior in electron regulation owing to the spontaneous charge rearrangement at the interface driven by the difference in work function and Fermi level between materials, [5] thereby influencing the catalytic activities. [6] Moreover, the electron transfer tendency in heterostructures can be managed by integrating materials with different work functions. [7] By integrating Au nanoparticles with higher work function (work function = 5.27 eV) and Fe 2 C nanoparticles (work function = 4.89 eV) into a Janus-like Au-Fe 2 C heterostructure, we recently demonstrated a catalytic radiotherapy owing to enriched charges of Au. [8] However, its efficiency is insufficient. The key to further increasing the catalytic activity lies Intracellular catalytic reactions can tailor tumor cell plasticity toward highefficiency treatments, but the application is hindered by the low efficiency of intracellular catalysis.Here, a magneto-electronic approach is developed for efficient intracellular catalysis by inducing eddy currents of FePt-FeC heterostructures in mild alternating magnetic fields (frequency of f = 96 kHz and amplitude of B ≤ 70 mT). Finite element simulation shows a high density of induced charges gathering at the interface of FePt-FeC heterostructure in the alternating magnetic field. As a result, the concentration of an essential coenzyme-β-nicotinamide adenine dinucleotide-in cancer cells is significantly reduced by the enhanced catalytic hydrogenation reaction of FePt-FeC heterostructures under alternating magnetic stimulation, leading to over 80% of senescent cancer cells-a vulnerable phenotype that facilitates further treatment. It is further demonstrated that senescent cancer cells can be efficiently killed by the chemodynamic therapy based on the enhanced Fentonlike reaction. By promoting intracellular catalytic reactions in tumors, this approach may enable precise catalytic tumor treatment.

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The molecular features of lung cancer stem cells in dedifferentiation process-driven epigenetic alterations

Masciale,

Banchelli,

Grisendi

et al. 2024

Journal of Biological Chemistry

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Toward a Reconceptualization of Stem Cells from Cellular Plasticity

Cited by 4 publications

References 56 publications

Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss

Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss

Magneto‐Electrically Enhanced Intracellular Catalysis of FePt‐FeC Heterostructures for Chemodynamic Therapy

The molecular features of lung cancer stem cells in dedifferentiation process-driven epigenetic alterations

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