Toward a science of translational science

Smith, Caleb; Baveja, Roohi; Grieb, Teri; Mashour, George A.

doi:10.1017/cts.2017.14

Cited by 14 publications

(8 citation statements)

References 20 publications

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“…Similarly, a shift toward widespread interest in translational medicine in recent years may be a contributing factor to necessitating faster publication times of the basic sciences. 18 Research on rates of basic science submission and the immediate impact of basic science in the clinical setting is scarce and future research investigating these matters is warranted.…”

Section: Discussionmentioning

confidence: 99%

Speed of Online and Print Peer-Reviewed Ophthalmology Publications and Correlation to Journal Bibliometric Measures

Nuesi

Kuriyan

Sridhar

2020

Journal of Academic Ophthalmology

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Objective This study aimed to explore the relationship between publishing speeds and peer-reviewed journal bibliometric measures in ophthalmology. Methods Journal Citation Reports and Scopus Database were accessed for identification of journal bibliometric measures in ophthalmology. Twelve randomly selected articles from 2018 for all identified journals were studied. All outcome measures were extracted from the full text of articles and correlated with journal bibliometric measures. Statistical analysis was performed on measured parameters in comparison to a previous study. Main Outcomes and Measures Journal impact factor, Eigenfactor score, and CiteScore were correlated with time from submission or acceptance of manuscripts to online and print publication. The correlation between study design and publishing speeds was also assessed. Results A total of 55 journals were included for a total of 657 articles. Online publications were significantly faster than print publications for almost every journal (p < 0.001). Laboratory experimental studies had significantly shorter times from submission to online publication (p = 0.002) and acceptance to online publication (p < 0.001) compared with observational and interventional studies. Journal impact factor was positively correlated to publishing speed from acceptance to online publication (p = 0.034). CiteScore was positively correlated to speed from submission to print publication (p = 0.04), acceptance to print publication (p = 0.013), and acceptance to online publication (p = 0.003). Eigenfactor score was not statistically significant when correlated with any outcome measures. Conclusion Online publication has increased speed of dissemination of knowledge in the ophthalmology literature. Despite reporting higher numbers of submissions every year, ophthalmology journals with higher bibliometric measures of impact tend to publish peer-reviewed articles faster than journals with lower impact scores. Study design of an article may affect its speed to publication.

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Section: Discussionmentioning

confidence: 99%

Speed of Online and Print Peer-Reviewed Ophthalmology Publications and Correlation to Journal Bibliometric Measures

Nuesi

Kuriyan

Sridhar

2020

Journal of Academic Ophthalmology

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“…The other major shift has been acceptance that translational research needs to be multidirectional, recognizing that data and observations from clinical practice, individual and collective behaviours are critical in creating real world impacts. (Woolf 2008;Cohrs et al, 2015;van der Laan and Boenink 2015;Jia 2016;Smith et al, 2017). The European Society for Translational Medicine (EUSTM) defines translational research as an interdisciplinary branch of the biomedical field supported by three main pillars: benchside, bedside and community.…”

Section: Evolving Definition Of Translation Researchmentioning

confidence: 99%

How 3D Printing Is Reshaping Translational Research

Sigston

2021

Front. Bioeng. Biotechnol.

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“Translational Research” has traditionally been defined as taking basic scientific findings and developing new diagnostic tools, drugs, devices and treatment options for patients, that are translated into practice, reach the people and populations for whom they are intended and are implemented correctly. The implication is of a unidirectional flow from “the bench to bedside”. The rapidly emergent field of additive manufacturing (3D printing) is contributing to a major shift in translational medical research. This includes the concept of bidirectional or reverse translation, early collaboration between clinicians, bio-engineers and basic scientists, and an increasingly entrepreneurial mindset. This coincides with, and is strongly complemented by, the rise of systems biology. The rapid pace at which this type of translational research can occur brings a variety of potential pitfalls and ethical concerns. Regulation surrounding implantable medical devices is struggling to keep up. 3D printing has opened the way for personalization which can make clinical outcomes hard to assess and risks putting the individual before the community. In some instances, novelty and hype has led to loss of transparency of outcomes with dire consequence. Collaboration with commercial partners has potential for conflict of interest. Nevertheless, 3D printing has dramatically changed the landscape of translational research. With early recognition and management of the potential risks, the benefits of reshaping the approach to translational research are enormous. This impact will extend into many other areas of biomedical research, re-establishing that science is more than a body of research. It is a way of thinking.

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“…Multidisciplinary approaches to address challenges in the treatment of diseases have almost become a must nowadays (Surkis et al, 2016). The adoption of other healthrelated areas of knowledge into the medical context have proved to bring complementary and supporting scientific evidence which, treated as required in some diseases, can be translated into more efficient treatments and new therapies (Smith, Baveja, Grieb, & Mashour, 2017). Potential health-allied disciplines such as food science can offer opportunities and tools never before considered neither foreseen in traditional approaches to disease management.…”

Section: Introductionmentioning

confidence: 99%

Lessons learnt from MyCyFAPP Project: Effect of cystic fibrosis factors and inherent-to-food properties on lipid digestion in foods

Calvo-Lerma

Asensio-Grau

Andrés

2020

Food Research International

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Unveiling mechanisms underpinning nutrient digestion has raised interest in the field of medical sciences for their potential application in clinical treatments. In the case of Cystic Fibrosis, there was the urgent need of understanding lipolysis to establish a criterion to adjust the dose of pancreatic enzyme supplements that patients have to take to allow digestion, given the associated exocrine pancreatic insufficiency (EPI). The aim of MyCyFAPP Project was establishing an evidence-based method to adjust pancreatic enzyme replacement therapy based on understanding lipolysis mechanisms. To solve this challenge, the still unexplored field of real foods digestion had to be addressed. A static in vitro digestion model that simulated different EPI intestinal conditions was developed to conduct an extensive experimental work with 52 foods and with different doses of the enzymatic supplements. Results could explain the role of the inherent to food and host factors affecting lipolysis. In addition, the prediction of the optimal dose of enzymes for all the studied foods was tested in a clinical trial resulting in improved growth and quality of life. This review paper provides an overview of the main findings related to the new knowledge generated in the field of lipid digestion in real foods.

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Toward a science of translational science

Cited by 14 publications

References 20 publications

Speed of Online and Print Peer-Reviewed Ophthalmology Publications and Correlation to Journal Bibliometric Measures

Speed of Online and Print Peer-Reviewed Ophthalmology Publications and Correlation to Journal Bibliometric Measures

How 3D Printing Is Reshaping Translational Research

Lessons learnt from MyCyFAPP Project: Effect of cystic fibrosis factors and inherent-to-food properties on lipid digestion in foods

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