Infiltration parameters and Manning's roughness are essential input parameters for surface irrigation simulation models. Multiple points of infiltration experiments require time-consuming, costly data collection and problematic calculations of field mean infiltration parameters. This study estimated the field mean infiltration parameters and Manning's roughness values on a regional scale, on the basis of closed-end furrow irrigation experiments conducted at 45 experimental sites on the Guanzhong plain, and evaluated the influence of Manning's roughness on advance trajectory and performance indicators of closed-end furrow irrigation. Then, we present a functional normalization of the Kostiakov equation and pedotransfer function (PTF) to estimate the normalization factors. The proposed method can be used to estimate the field mean infiltration parameters using PTF and the represented Manning's roughness to determine the optimal discharge of closed-end furrow irrigation. The results revealed that the advance trajectory and performance of closed-end furrow irrigation was not sensitive to variations of Manning's roughness, which can be adopted as a representative value (i.e., 0.075) of the maize field. The normalization method was proven to be feasible for the Kostiakov equation, and the PTF reliably estimated the normalization factors. Last, the optimized values of the inflow discharge were determined using the proposed method, with various combinations of furrow lengths and bottom slopes in the study area, and also compared with the inflow discharge determined based on infiltration parameters and Manning's roughness, which were inversed by SIPAR_ID. The results indicated that the inflow discharge values obtained through using the two methods were approximately equal, proving that the proposed method was reliable and easy to use in practice.