Toward an Information Theory of Quantitative Genetics

Abstract

Quantitative genetics has evolved dramatically in the past century, and the proliferation of genetic data, in quantity as well as type, enables the characterization of complex interactions and mechanisms beyond the scope of its theoretical foundations. In this article, we argue that revisiting the framework for analysis is important and we begin to lay the foundations of an alternative formulation of quantitative genetics based on information theory. Information theory can provide sensitive and unbiased measures of statistical dependencies among variables, and it provides a natural mathematical language for an alternative view of quantitative genetics. In the previous work, we examined the information content of discrete functions and applied this approach and methods to the analysis of genetic data. In this article, we present a framework built around a set of relationships that both unifies the information measures for the discrete functions and uses them to express key quantitative genetic relationships. Information theory measures of variable interdependency are used to identify significant interactions, and a general approach is described for inferring functional relationships in genotype and phenotype data. We present information-based measures of the genetic quantities: penetrance, heritability, and degrees of statistical epistasis. Our scope here includes the consideration of both two- and three-variable dependencies and independently segregating variants, which captures additive effects, genetic interactions, and two-phenotype pleiotropy. This formalism and the theoretical approach naturally apply to higher multivariable interactions and complex dependencies, and can be adapted to account for population structure, linkage, and nonrandomly segregating markers. This article thus focuses on presenting the initial groundwork for a full formulation of quantitative genetics based on information theory.

Multiple indicators metrological analysis for 5 kinds of tea produced in Yunnan, China

“…Construction of a multi-index analysis and comprehensive evaluation system by entropy analysis According to combustion heat, differential thermogravimetric, fat content, crude fiber content, ash content, and trace element content data for 5 kinds of tea, multi-index comprehensive evaluation systems for 5 kinds of tea, including camphorscented palace tea, fossil glutinous rice tea, old tree white tea, Brown Mountain ancient tree tea, and pure Banzhang tea, were established by the entropy method (Aide et al, 2021;Álvarez et al, 2020;Arch-Tirado et al, 2020;Bostian et al, 2020;Chen et al, 2020;Cho, 2020). (Deng et al, 2020;Galas et al, 2021;Gupta & Chokshi, 2020;Hu et al, 2020) According to the characteristics of entropy, this paper judges the randomness and degree of disorder of an event by calculating the entropy value and judges the degree of dispersion of an index by using the entropy value. The greater the dispersion degree of the index is, the greater the influence (weight) of the index on the comprehensive evaluation, and the smaller the entropy value.…”