Toward an Integrated View of Operational Tolerance in Human Renal Transplantation: A Systems Biology Perspective

Editorial: Recent advances on omics and biomarkers research in renal transplantation

“…Raïch-Regué et al used immunohistochemistry to show that p-S6RP in the peritubular capillary endothelia was associated with circulating human leukocyte antigens (HLA)-DSA in transplanted kidney tissue biopsies and first suggested that it could be used as a sensitive alternative biomarker for HLA-DSA to diagnose ABMR when DSA was not available or not yet detected. Renal operational tolerance, defined as the condition in which a SOT recipient retains stable graft function and lacks histological signs of rejection, after at least 1 year of immunosuppressant discontinuation ( 5 ), is a rare but beneficial condition. To investigate the underlying mechanism of this phenomenon, Massart et al identified the variation of HOMER36, IQCH, and LCN36 in two tolerant patients and three controls by using exome sequencing technology.…”