Toward an Understanding of the Pathophysiology of Huntington’s Chorea

Klawans, H.L.; Ilahi, M. M.; Ringel, Steven P.

doi:10.1159/000103145

Cited by 25 publications

(3 citation statements)

References 11 publications

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“…The theoretical basis for the use of haloperidol in the treatment of L-dopa induced dyskinesias is derived from a theory of the pathogenesis of choreatic movements first proposed by Klawans et al (1971). These authors proposed that the abnormal choreiform movements in Huntington's chorea are due to an exaggerated or altered facilitatory effect of dopamine acting upon altered striatal neurones causing them to fire abnormally.…”

Section: Discussionmentioning

confidence: 99%

Attempted use of haloperidol in the treatment of L-dopa induced dyskinesias

Klawans

Weiner

1974

Journal of Neurology, Neurosurgery & Psychiatry

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SYNOPSIS Haloperidol was used in 12 patients in an attempt to improve L-dopa induced dyskinesias. In eight patients any improvement in dyskinesias was associated with increased Parkinsonism. In four patients the dyskinesias initially improved without clinical deterioration. Within several weeks, however, the disability due to Parkinsonism increased in these four patients as well. These observations suggest that long term haloperidol does not effectively decrease L-dopa induced dyskinesias without worsening Parkinsonism.

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Section: Discussionmentioning

confidence: 99%

Attempted use of haloperidol in the treatment of L-dopa induced dyskinesias

Klawans

Weiner

1974

Journal of Neurology, Neurosurgery & Psychiatry

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“…If such hypersensitivity occurred, normal or even decreased levels of dopamine might elicit an increased dopamine response. The mechanism of increased receptor site sensitivity has been proposed as part of the pathophysiology of several human movement disorder including levodopa-induced dyskinesias Carlsson, 1970), Huntington's disease (Klawans et al, 1971), tardive dyskinesia (Klawans, 1973). and hyperthyroid chorea (Klawans, Shenker, 1972).…”

mentioning

confidence: 99%

On the role of dopamine in the pathophysiology of anorexia nervosa

Barry¹,

Klawans

1976

J. Neural Transmission

127

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Based on a review of the pathophysiology of the major symptoms of anorexia nervosa, it was suggested that increased activity of dopamine at central dopamine receptors plays a role in the pathophysiology of this disorder. Although dopamine receptor site hypersensitivity, or synthesis, of a false transmitter could account for this, a defect in negative feedback control mechanisms is more consistent with the known characteristics of anorexia nervosa. The possible role of pure dopamine antagonists in symptomatic treatment and of dopamine agonists in reversing this disorder was discussed.

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“…The increase of plasma GH levels may depend upon a dopaminergic predominance, as postulated in Huntington's chorea (17). How ever, the data obtained using pharmacological agents which interfere with dopamine metab olism and dopamine receptor sites are often at variance (5,8,12,19,25).…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Nocturnal Plasma Prolactin and Growth Hormone Secretion in Patients with Parkinson’s Disease and Huntington’s Chorea

et al. 1980

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Plasma prolactin (PRL) and growth hormone (GH) levels were measured in 8 patients with Parkinson’s disease (PD) and in 6 patients with Huntington’s chorea (HC) during the night. The sleep was evaluated with all-night poligraphic recordings. Plasma PRL levels were significantly lower in parkinsonian patients than in age-matched controls. Plasma GH values did not differ between the two groups. In HC patients no statistically significant differences were found in the PRL and GH secretory patterns when compared to the age-matched control subjects. These data indicate that changes of nocturnal PRL and GH profile in PD and HC patients in respect to age-matched healthy subjects, may be present, but a straight forward differentiation among groups is not possible because of the wide individual variations.

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Toward an Understanding of the Pathophysiology of Huntington’s Chorea

Cited by 25 publications

References 11 publications

Attempted use of haloperidol in the treatment of L-dopa induced dyskinesias

Attempted use of haloperidol in the treatment of L-dopa induced dyskinesias

On the role of dopamine in the pathophysiology of anorexia nervosa

Spontaneous Nocturnal Plasma Prolactin and Growth Hormone Secretion in Patients with Parkinson’s Disease and Huntington’s Chorea

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