Cement production is one of the major sources of decomposition of carbonates leading to the emission of carbon dioxide. Researchers have proven that incorporating industrial wastes is of paramount significance for producing green concrete due to the benefits of reducing cement production. The compressive strength of concrete is an imperative parameter to consider when designing concrete structures. Considering high prediction capabilities, artificial intelligence models are widely used to estimate the compressive strength of concrete mixtures. A variety of artificial intelligence models have been developed in the literature; however, evaluation of the modeling procedure and accuracy of the existing models suggests developing such models that manifest the detailed evaluation of setting parameters on the performance of models and enhance the accuracy compared to the existing models. In this study, the computational capabilities of the adaptive neurofuzzy inference system (ANFIS), gene expression programming (GEP), and gradient boosting tree (GBT) were employed to investigate the optimum ratio of ground-granulated blast furnace slag (GGBFS) and fly ash (FA) to the binder content. The training process of GEP modeling revealed 200 chromosomes, 5 genes, and 12 head sizes as the best hyperparameters. Similarly, ANFIS hybrid subclustering modeling with aspect ratios of 0.5, 0.1, 7, and 150; learning rate; maximal depth; and number of trees yielded the best performance in the GBT model. The accuracy of the developed models suggests that the GBT model is superior to the GEP, ANFIS, and other models that exist in the literature. The trained models were validated using 40% of the experimental data along with parametric and sensitivity analysis as second level validation. The GBT model yielded correlation coefficient (R), mean absolute error (MAE), and root mean square error (RMSE), equaling 0.95, 3.07 MPa, and 4.80 MPa for training, whereas, for validation, these values were recorded as 0.95, 3.16 MPa, and 4.85 MPa, respectively. The sensitivity analysis revealed that the aging of the concrete was the most influential parameter, followed by the addition of GGBFS. The effect of the contributing parameters was observed, as corroborated in the literature.