Toward Chemical Ecology of Plant-Parasitic Nematodes: Kairomones, Pheromones, and Other Behaviorally Active Chemical Compounds

Čepulytė, Rasa; Būda, Vincas

doi:10.1021/acs.jafc.1c04833

Cited by 10 publications

(6 citation statements)

References 128 publications

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“…This work harnesses chemical communication between plants and nematodes [47][48][49] to identify small molecules that are detected by the chemosensory nervous system. Our approach relies on testing small molecules synthesized by plants for their ability to either attract or repel the model roundworm, Caenorhabditis elegans.…”

Section: Resultsmentioning

confidence: 99%

An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence inC. elegans

Fryer,

Guha,

Rogel-Hernandez

et al. 2023

Preprint

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Throughout history, humans have relied on plants as a source of medication, flavoring, and food. Plants synthesize large chemical libraries and release many of these compounds into the rhizosphere and atmosphere where they affect animal and microbe behavior. To survive, nematodes must have evolved the sensory capacity to distinguish plant-made small molecules (SMs) that are harmful and must be avoided from those that are beneficial and should be sought. This ability to classify chemical cues as a function of their value is fundamental to olfaction, and represents a capacity shared by many animals, including humans. Here, we present an efficient platform based on multi-well plates, liquid handling instrumentation, low-cost optical scanners, and bespoke software that can efficiently determine the chemotaxis valence of single SMs in the model nematode,Caenorhabditis elegans. Using this integrated hardware-wetware-software platform, we screened 90 plant SMs and identified 37 that attracted or repelled wild-type animals, but had no effect on mutants defective in chemosensory transduction. Genetic dissection indicates that for at least 10 of these SMs, response valence emerges from the integration of opposing signals, arguing that olfactory valence is often determined by integrating chemosensory signals over multiple lines of information. This study establishes that C. elegans is an effective discovery engine for determining chemotaxis valence and for identifying natural products detected by the chemosensory nervous system.

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Section: Resultsmentioning

confidence: 99%

An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence inC. elegans

Fryer,

Guha,

Rogel-Hernandez

et al. 2023

Preprint

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show abstract

“…All that is required is a shift in thinking so that the response of the system to a basket of stressors dominates the debate rather than the current silo approach of looking at the dose of single stressors in isolation. In chemical ecology, the chemicals function as highly sensitive communicators of information to receptors [ 76 , 77 , 78 , 79 , 80 , 81 ]. These may be predators responding to messages alerting them to the presence of prey (known as kairomones), prey responding to signals from predators (allomones) or signals from potential mates (pheromones).…”

Section: Chemical Ecology Mychorrysal and Microbiome Evidencementioning

confidence: 99%

Low Dose and Non-Targeted Radiation Effects in Environmental Protection and Medicine—A New Model Focusing on Electromagnetic Signaling

Mothersill

Cocchetto

Seymour

2022

IJMS

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The role of signalling in initiating and perpetuating effects triggered by deposition of ionising radiation energy in parts of a system is very clear. Less clear are the very early steps involved in converting energy to chemical and biological effects in non-targeted parts of the system. The paper aims to present a new model, which could aid our understanding of the role of low dose effects in determining ultimate disease outcomes. We propose a key role for electromagnetic signals resulting from physico-chemical processes such as excitation decay, and acoustic waves. These lead to the initiation of damage response pathways such as elevation of reactive oxygen species and membrane associated changes in key ion channels. Critically, these signalling pathways allow coordination of responses across system levels. For example, depending on how these perturbations are transduced, adverse or beneficial outcomes may predominate. We suggest that by appreciating the importance of signalling and communication between multiple levels of organisation, a unified theory could emerge. This would allow the development of models incorporating time, space and system level to position data in appropriate areas of a multidimensional domain. We propose the use of the term “infosome” to capture the nature of radiation-induced communication systems which include physical as well as chemical signals. We have named our model “the variable response model” or “VRM” which allows for multiple outcomes following exposure to low doses or to signals from low dose irradiated cells, tissues or organisms. We suggest that the use of both dose and infosome in radiation protection might open up new conceptual avenues that could allow intrinsic uncertainty to be embraced within a holistic protection framework.

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“…3,4 The use of chemical means to control plant parasitic nematodes is still the most effective method of nematode control. 5 Nevertheless, the effects of chemical nematicides on the environment and the potential safety factors are increasingly forcing chemical nematicides to be banned. 6 Consequently, the need for new and safe nematode control methods is urgent and is becoming increasingly important.…”

Section: Introductionmentioning

confidence: 99%

“…RKN has strong infectivity and a wide range of hosts; thus, crops have to be carefully screened before planting 3,4 . The use of chemical means to control plant parasitic nematodes is still the most effective method of nematode control 5 . Nevertheless, the effects of chemical nematicides on the environment and the potential safety factors are increasingly forcing chemical nematicides to be banned 6 .…”

Section: Introductionmentioning

confidence: 99%

Aspergillus niger produces lethal compounds against nematodes

Zhang

Cui

et al. 2023

Pest Management Science

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BackgroundAspergillus niger is generally considered safe and is widely used across a broad range of industries from food to pharmaceuticals. The metabolites of some Aspergillus species are effective in killing nematodes. The active ingredients that play a role are citric acid and oxalic acid.ResultsThe effective nematocidal metabolite in the fermentation broth of the A. niger Ym16 is a calcium oxalate coordination compound (C2H2O4•2(C2HO4)•C2O4•4(H2O)•2(Ca)). The mortality of fermentation broth and compound solution to second‐stage juveniles (J2s) of Meloidogyne incognita were 94% (8 h) and 95% (2 h), respectively. The hatching inhibition rates of fermentation broth and compound solution to eggs of M. incognita were 86% (24 h) and 87% (12 h), respectively. Furthermore, the Ym16 strain promoted plant growth.ConclusionStrain Ym16 and its metabolites should be the first choice for nematode control because it is an effective agent against soil nematodes. © 2023 Society of Chemical Industry.

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Toward Chemical Ecology of Plant-Parasitic Nematodes: Kairomones, Pheromones, and Other Behaviorally Active Chemical Compounds

Cited by 10 publications

References 128 publications

An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence inC. elegans

An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence inC. elegans

Low Dose and Non-Targeted Radiation Effects in Environmental Protection and Medicine—A New Model Focusing on Electromagnetic Signaling

Aspergillus niger produces lethal compounds against nematodes

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