We report results from the first Earth-space VLBI observations of the Galactic Center supermassive black hole, Sgr A * . These observations used the space telescope Spektr-R of the RadioAstron project together with a global network of 20 ground telescopes, observing at a wavelength of 1.35 cm. Spektr-R provided baselines up to 3.9 times the diameter of the Earth, corresponding to an angular resolution of approximately 55 𝜇as and a spatial resolution of 5.5𝑅 Sch at the source, where 𝑅 Sch ≡ 2𝐺 𝑀/𝑐 2 is the Schwarzschild radius of Sgr A * . Our short ground baseline measurements ( < ∼ 80 M𝜆) are consistent with an anisotropic Gaussian image, while our intermediate ground baseline measurements (100−250 M𝜆) confirm the presence of persistent image substructure in Sgr A * . Both features are consistent with theoretical expectations for strong scattering in the ionized interstellar medium, which produces Gaussian scatter-broadening on short baselines and refractive substructure on long baselines. We do not detect interferometric fringes on any of the longer ground baselines or on any ground-space baselines. While space VLBI offers a promising pathway to sharper angular resolution and the measurement of key gravitational signatures in black holes, such as their photon rings, our results demonstrate that space VLBI studies of Sgr A * will require sensitive observations at submillimeter wavelengths.