Psychotherapy integration leaders have recently asserted that the future of psychotherapy will involve incorporation of neuroscience. In the past 18 years, techniques have been discovered and developed to treat trauma and dissociation at all three neurobiological levels of Porges' (2001, 2007) polyvagal theory. This approach is known as Observed & Experiential Integration (OEI). The originator incorporated elements of Focusing, Eye Movement Desensitization and Reprocessing, and Educational Kinesiology. OEI theory emerged from experiential psychotherapy, and relational psychoanalytic and behavioral concepts were assimilated during 45,000 hours of psychotherapy. Five sets of OEI techniques are used for titration of affective and somatic intensity, reduction of negative transference, and deepening of social connection. OEI involves neuro-activation & microattunement (NAMA). It has been applied with body therapies and neurotherapy and used with children, couples, and families. OEI has also been applied to addictive and self-destructive urges, panic attacks, and eating disorders. Case examples illustrate applications of this treatment.