Toward genetic dissection of high and low antibody responsiveness in Biozzi mice

Puel, Anne; Mevel, Jean-Claude; Bouthillier, Y; Feingold, N; Fridman, Wolf‐Herman; Mouton, D

doi:10.1073/pnas.93.25.14742

Cited by 37 publications

(11 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With this in mind, several studies have sought to identify individuals within populations with H or L immune responses. Studies of mice have shown that selection for H or L antibody to sheep red blood cells is inversely associated with CMIR, and that the H antibody is associated with control of extracellular pathogens, but not intracellular organisms [13]. Studies of chickens also selected for the H or L antibody have reported similar findings [6,16].…”

Section: Discussionsupporting

confidence: 61%

Evaluation of immune responses of cattle as a means to identify high or low responders and use of a human microarray to differentiate gene expression

2003

View full text Add to dashboard Cite

-An immune response (IR) index to identify cows with high (H) and low (L) antibodymediated immune responses (AMIR) had been previously devised. High AMIR associated with decreased mastitis and improved response to vaccination. Measurement of cell-mediated immune response (CMIR) was not included in the index; therefore various antigen/adjuvant combinations were evaluated as inducers of DTH to be added to the IR-index. The Bacillus Calmette Guérin (BCG)-induced/purified protein derivative (PPD)-elicited tuberculin skin test is a reliable measure of DTH; however, its use to identify livestock with high CMIR may be confounded due to previous exposure to Mycobacteria tuberculosis. DTH to BCG/PPD was therefore compared with that induced by Mycobacteria phlei (saprophyte) and its derivative phlein as the test antigen. Antibody to OVA was also evaluated. The results indicated that BCG/PPD and M. phlei/phlein induced similar DTH, but cross reaction to PPD was evident following induction of DTH using M. phlei making it a less than ideal alternative for testing livestock. Nonetheless, cows could be ranked for both AMIR and CMIR. RNA from two cows with the highest and lowest IR ranks was then used to probe a human 1.7 kD microarray to determine the ability of a human array to provide information on bovine genes associated with H and L. dairy cows / antibody response / delayed-type hypersensitivity / selection / microarray

show abstract

Section: Discussionsupporting

confidence: 61%

Evaluation of immune responses of cattle as a means to identify high or low responders and use of a human microarray to differentiate gene expression

2003

View full text Add to dashboard Cite

show abstract

“…Approximately ten independently segregating loci endowed with additive effects are responsible for the major (240-fold) multispecific differences separating high- and low-antibody responders [15,16]. No similar data are available for T cell responses in general, and those against histocompatibility antigens in particular.…”

Section: Introductionmentioning

confidence: 99%

Prediction of Graft-Versus-Host Disease in Humans by Donor Gene-Expression Profiling

Baron

Somogyi²,

Greller³

et al. 2007

PLoS Med

View full text Add to dashboard Cite

BackgroundGraft-versus-host disease (GVHD) results from recognition of host antigens by donor T cells following allogeneic hematopoietic cell transplantation (AHCT). Notably, histoincompatibility between donor and recipient is necessary but not sufficient to elicit GVHD. Therefore, we tested the hypothesis that some donors may be “stronger alloresponders” than others, and consequently more likely to elicit GVHD.Methods and FindingsTo this end, we measured the gene-expression profiles of CD4+ and CD8+ T cells from 50 AHCT donors with microarrays. We report that pre-AHCT gene-expression profiling segregates donors whose recipient suffered from GVHD or not. Using quantitative PCR, established statistical tests, and analysis of multiple independent training-test datasets, we found that for chronic GVHD the “dangerous donor” trait (occurrence of GVHD in the recipient) is under polygenic control and is shaped by the activity of genes that regulate transforming growth factor-β signaling and cell proliferation.ConclusionsThese findings strongly suggest that the donor gene-expression profile has a dominant influence on the occurrence of GVHD in the recipient. The ability to discriminate strong and weak alloresponders using gene-expression profiling could pave the way to personalized transplantation medicine.

show abstract

“…Several genes involved in inflammation and the immune system are located in the regions of the markers identified: TNF superfamily members Tnfsf4 , 6 , and 8 (chr.1, 84.9–85 cM) which are involved in T cell activation [37,38]; three selectin genes ( Sele, Sell, Selp , chr.1, 86.6 cM) which are involved in immune cell infiltration into inflamed tissues [39]; several members of immune cell surface proteins of the Slam family ( slamf1, 2, 5, 6 , and 9 ; chr.1, 89.5–93.3 cM) [40]; the chemokine gene Xcl1 (chr.1, 87 cM) which is expressed by mast cells and recruits lymphocytes [41]; several immunoglobulin Fc receptor genes ( Fcrl3 , Fcgr2b , and Fcgr3 at chr.1, 92.3 cM; Fcer1g at chr.1, 93.3 cM; Fcer1a at chr.1, 94.2 cM); the flagellin receptor Tlr5 (chr.1, 98 cM); Mmp3 (chr.9, 1 cM) which recruits CD4+ lymphocytes [42]; Mmp7 (chr.9, 1 cM) which activates Paneth cell-derived cryptdins (α-defensins) [43]; Icam1 (chr.9, 7 cM) which is involved in lymphocyte infiltration into inflamed tissues [44]; Kitl (chr.10, 57 cM) which is also known as stem cell factor, and is crucial for mast cell differentiation [45]; Im5 (chr.10, 65 cM) which is involved in antibody-responsiveness [46]; Lyzs (chr.10, 66 cM) which is a Paneth cell product that digests cell walls of bacteria [47]; Ifng (chr.10, 67 cM) which is an important inflammatory signal in CF as well as other conditions [48]; Il22 (chr.10, 67 cM), a member of the anti-inflammatory IL-10 interleukin family [49]; and the Stat2 and 6 genes (chr.10, 70 cM) which are important components of intracellular signaling pathways [50]. …”

Section: Resultsmentioning

confidence: 99%

Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10

Norkina

Lisle

2005

BMC Genet

View full text Add to dashboard Cite

Background: Although cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the severity of disease is highly variable indicating the influence of modifier genes. The intestines of Cftr deficient mice (CF mice: Cftr tm1Unc ) are prone to obstruction by excessive mucus accumulation and are used as a model of meconium ileus and distal intestinal obstruction syndrome. This phenotype is strongly dependent on the genetic background of the mice. On the C57Bl/6 background, the majority of CF mice cannot survive on solid mouse chow, have inflammation of the small intestine, and are about 30% smaller than wild type littermates. In this work potential modifier loci of the CF intestinal phenotype were identified.

show abstract

Toward genetic dissection of high and low antibody responsiveness in Biozzi mice

Abstract: Several distinct chromosomal segments were recently identified by cosegregation analysis of polymorphic markers with antibody responsiveness in an

Cited by 37 publications

References 34 publications

Evaluation of immune responses of cattle as a means to identify high or low responders and use of a human microarray to differentiate gene expression

Evaluation of immune responses of cattle as a means to identify high or low responders and use of a human microarray to differentiate gene expression

Prediction of Graft-Versus-Host Disease in Humans by Donor Gene-Expression Profiling

Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10

Contact Info

Product

Resources

About