Globalization has led to a rapid increase in migration, placing an extraordinary stress on the migrants and their families, which may give rise to comparable increases in all types of mental illness. Mental health problems or distress for migrants result from a complex interplay between biological, psychological, social and environmental factors. One group of people that have been migrating in great numbers are the Filipinos. Currently, Taiwan has about 94,892 migrant workers from the Philippines. Research indicated that the coping styles of Filipinos, nested in a collectivist culture, may not always work in other settings. Religion and prayer are generally used by the Filipino migrants to cope with distress. This study, therefore, used the data from 378 participants and employed incremental validity analysis to look at the significance of psycho-social and religiousspiritual coping resources in buffering mental distress and promoting wellbeing of the Filipino Catholic migrants in Taiwan. After controlling for the relevant demographics in the hierarchical regression analyses, the subsequent steps indicated that Mastery in Step 2, Social Connectedness in Step 3, Positive Religious Coping in Step 4, and finally Spiritual Meaning in Step 5 significantly predicted both distress and well-being. Although entered in Step 4 and Step 5 of the regression equation, both Religious Coping and Spiritual Meaning, respectively, made a significant incremental contribution to coping with distress and promoting well-being. These significant results suggest that the individuals and church communities, social welfare organizations and policy makers on migrant issues should take into consideration the psycho-social and religious-spiritual resources that help the migrants cope with distress and promote well-being.