Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting

KleinJan, G.H.; Berg, Nynke S. van den; Oosterom, Matthias N. van; Wendler, Thomas; Miwa, Makoto; Bex, Axel; Hendricksen, Kees; Horenblas, Simon; Leeuwen, Fijs W. B. van

doi:10.2967/jnumed.115.171645

Cited by 39 publications

(34 citation statements)

References 17 publications

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“…Indeed, extraluminal assessment of tumor could be incorporated into an augmented reality format, with an overlay of the malignant potential of each tissue in the surgeon's operative view. The feasibility of augmented reality technologies in the operating room is an area of current exploration . Augmented reality technologies, such as Google Glass or Microsoft Hololens, are widely currently available, and the addition of hyperspectral sensing information could allow for improved identification of colorectal cancers, recognition of malignancy in peritoneal implants, and detection of synchronous, undiagnosed malignancy in other areas of the bowel or within sentinel lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Automated diagnosis of colon cancer using hyperspectral sensing

Beaulieu

Goldstein

Singh

et al. 2018

Robotics Computer Surgery

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Section: Discussionmentioning

confidence: 99%

Automated diagnosis of colon cancer using hyperspectral sensing

Beaulieu

Goldstein

Singh

et al. 2018

Robotics Computer Surgery

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“…Ook het gebruik van een hybride tracer en navigatie is onderwerp van onderzoek geweest [15][16][17][18]. Niet door ons onderzocht, maar wel aannemelijk, is het gemak van overdracht van kennis en kunde op een afdeling waar ruime expertise aanwezig is over de behandeling van een tumortype.…”

Section: Andere Effecten Van Concentratieunclassified

Behandeling van peniscarcinoom

Horenblas

2017

Tijdschr Urol

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Samenvatting De concentratie van de behandeling van peniskankerpatiënten in het Antoni van Leeuwenhoek heeft zich in een periode van ongeveer 10 jaar voltrokken, zonder bemoeienissen van welke instantie dan ook. Deze ongedwongen verandering in de behandelpraktijk van urologen in Nederland is het resultaat van door collegae erkende expertise, gebaseerd op veelvuldig gepubliceerd en uitgedragen onderzoek. Deze concentratie heeft geresulteerd in: 1) De kwaliteit van de zorg is toegenomen en behoort wereldwijd tot de beste, afgaande op de overlevingscijfers. 2) De concentratie van patiënten heeft de mogelijkheden geschapen om onderzoek te doen naar: a) de effectiviteit van de behandeling, b) de introductie van nieuwe behandelingen en c) onderzoek naar de oorzaak van peniscarcinoom. Daarnaast heeft de concentratie van patiënten bijgedragen aan de wereldwijde discussie over centralisatie. De behandeling van het peniscarcinoom in ons land kan als voorbeeld dienen van hoe concentratie gunstig kan uitpakken voor de kwaliteit van de zorg. Als zodanig kan de behandeling dienen als een voorbeeld voor centralisatie bij andere typen tumoren, indien aan de voorwaarden van algemeen erkende expertise wordt voldaan. The treatment of penis cancerAn example for centralization?Abstract Within a period of 10 years we have witnessed a change in the referral pattern of penis cancer patients. Almost 75% of Dutch penis cancer patients are being referred to the Netherlands Cancer Institute Antoni van Leeuwenhoek. This was not due to a deliberate health policy, but a voluntary change due to recognized expertise based on extensive presentations and publications of the department. This concentration has resulted in: 1) Increase of the quality of care as seen by increased survival figures. 2) The concentration of penis cancer patients in one institute has led to analyses of the results of the various treatments and led to improvements of the treatment worldwide.3) The concentration of patients was also instrumental in the initiation of research into the etiology of penis cancer and quality of life. The treatment of penis cancer in the Netherlands can be exemplary for the effects of centralization, assuming that the conditions for recognized expertise are present.

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“…Through this connection, it has become possible to create surgical navigation setups that realize positional tracking of fluorescence cameras in pre-or intraoperative 3-D imaging data sets. [4][5][6] Combined with futuristic virtual and augmented reality-based computer-assisted surgery techniques, these approaches extend the use of fluorescence guidance toward lesions that lie beyond the depth-related fluorescence detection limits (i.e., >1 cm deep).…”

Section: Introductionmentioning

confidence: 99%

“…Initial studies, using a near-infrared (NIR) optical tracking system (OTS) and tracking fiducials placed on both the fluorescence camera and the patient, helped to demonstrate the potential of this navigated fluorescence camera concept in a variety of settings. 4,5,7,8 Unfortunately, in some of the open surgical procedures, the OTS caused an interfering flickering signal that prevented fluorescence imaging (see Figs. 1-3).…”

Section: Introductionmentioning

confidence: 99%

Navigating surgical fluorescence cameras using near-infrared optical tracking

et al. 2018

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Fluorescence guidance facilitates real-time intraoperative visualization of the tissue of interest. However, due to attenuation, the application of fluorescence guidance is restricted to superficial lesions. To overcome this shortcoming, we have previously applied three-dimensional surgical navigation to position the fluorescence camera in reach of the superficial fluorescent signal. Unfortunately, in open surgery, the near-infrared (NIR) optical tracking system (OTS) used for navigation also induced an interference during NIR fluorescence imaging. In an attempt to support future implementation of navigated fluorescence cameras, different aspects of this interference were characterized and solutions were sought after. Two commercial fluorescence cameras for open surgery were studied in (surgical) phantom and human tissue setups using two different NIR OTSs and one OTS simulating light-emitting diode setup. Following the outcome of these measurements, OTS settings were optimized. Measurements indicated the OTS interference was caused by: (1) spectral overlap between the OTS light and camera, (2) OTS light intensity, (3) OTS duty cycle, (4) OTS frequency, (5) fluorescence camera frequency, and (6) fluorescence camera sensitivity. By optimizing points 2 to 4, navigation of fluorescence cameras during open surgery could be facilitated. Optimization of the OTS and camera compatibility can be used to support navigated fluorescence guidance concepts.

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Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting

Cited by 39 publications

References 17 publications

Automated diagnosis of colon cancer using hyperspectral sensing

Automated diagnosis of colon cancer using hyperspectral sensing

Behandeling van peniscarcinoom

Navigating surgical fluorescence cameras using near-infrared optical tracking

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