2016
DOI: 10.1364/boe.7.000279
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Toward in vivo biopsy of melanoma based on photoacoustic and ultrasound dual imaging with an integrated detector

Abstract: Melanoma is the most dangerous type of skin cancer with high lethal rate. Tumor thickness and tumor-associated vasculature are two key parameters for staging melanoma. Previous techniques for diagnosing melanoma have insurmountable restrictions, such as invasive, low specificity, or inaccurate depth measurement. Here we develop an integrated photoacoustic (PA) and ultrasound (US) imaging system dedicated to overcome these limitations. An integrated detector with sound-light coaxial/confocal design and flexible… Show more

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Cited by 57 publications
(44 citation statements)
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“…Optical resolution photoacoustic microscopy (ORPAM), a hybrid optical imaging modality integrating high spatial resolution, rich contrast of hemoglobin and deep acoustic penetration depth, has been successfully applied in biology and medicine . However, limited by the conventional raster scanning mechanism, existing ORPAMs suffers from relative translation between imaging interface and the sample as well as subcentimeter FOV .…”
Section: Introductionmentioning
confidence: 99%
“…Optical resolution photoacoustic microscopy (ORPAM), a hybrid optical imaging modality integrating high spatial resolution, rich contrast of hemoglobin and deep acoustic penetration depth, has been successfully applied in biology and medicine . However, limited by the conventional raster scanning mechanism, existing ORPAMs suffers from relative translation between imaging interface and the sample as well as subcentimeter FOV .…”
Section: Introductionmentioning
confidence: 99%
“…35 In addition, some multimodality imaging methods are also widely used, such as PA/US imaging system; an integrated detector with sound-light coaxial/confocal design and°exible coupling mode is employed for the combined PA/US imaging strategy. [36][37][38] This method is able to simultaneously detect the absorption of chromophores such as hemoglobin and melanin and the di®erences in acoustic impedance.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] It overcomes the resolution disadvantages of pure optical imaging and the contrast disadvantages of pure ultrasound imaging, bene¯ting from the capacity of high-resolution sensing optical contrast at depths beyond the optical transport mean-free-paths. [20][21][22][23][24][25][26][27][28][29][30][31][32][33] PA imaging is based on the PA e®ect. 34 When irradiated by pulsed laser, tissue absorbs the optical energy and converts it into ultrasound due to thermal expansion, which then can be detected by transducers.…”
Section: Introductionmentioning
confidence: 99%