Toward integrative approaches to study the causal role of neural oscillations via transcranial electrical stimulation

Beliaeva, Valeriia; Savvateev, Iurii; Zerbi, Valerio; Polanía, Rafael

doi:10.1038/s41467-021-22468-7

Cited by 41 publications

(26 citation statements)

References 99 publications

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“…Employing low-frequency tACS to downregulate gamma oscillation 44 , 45 or using 30 Hz tACS might have been more effective in decreasing WM capacity than applying 40 Hz tACS. Additionally, utilizing brain imaging methods would be necessary to further validate such mechanisms involving WM; indeed, integrative approach, including imaging methods, in neurostimulation experiments is suggested to be critical to define causal role of neural oscillations 46 . In the present study, we could not record EEG signals while the participants were performing behavioral tasks, as the tasks were performed simultaneously with the stimulation; EEG recorded simultaneously with the stimulations would distort the waveforms and might contain severe artifacts.…”

Section: Discussionmentioning

confidence: 99%

80 Hz but not 40 Hz, transcranial alternating current stimulation of 80 Hz over right intraparietal sulcus increases visuospatial working memory capacity

Park

Lee

et al. 2022

Sci Rep

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Working memory (WM) is a complex cognitive function involved in the temporary storage and manipulation of information, which has been one of the target cognitive functions to be restored in neurorehabilitation. WM capacity is known to be proportional to the number of gamma cycles nested in a single theta cycle. Therefore, gamma-band transcranial alternating current stimulation (tACS) should be dependent of the stimulation frequency; however, the results of previous studies that employed 40 Hz tACS have not been consistent. The optimal locations and injection currents of multiple scalp electrodes were determined based on numerical simulations of electric field. Experiments were conducted with 20 healthy participants. The order of three stimulation conditions (40 Hz tACS, 80 Hz tACS, and sham stimulation) were randomized but counterbalanced. Visual hemifield-specific visual WM capacity was assessed using a delayed visual match to the sample task. High gamma tACS significantly increased WM capacity, while low gamma tACS had no significant effect. Notably, 80 Hz tACS increased WM capacity on both the left and right visual hemifields, while previous tACS studies only reported the effects of tACS on contralateral hemifields. This is the first study to investigate the frequency-dependent effect of gamma-band tACS on WM capacity. Our findings also suggest that high gamma tACS might influence not only WM capacity but also communication between interhemispheric cortical regions. It is expected that high gamma tACS could be a promising neurorehabilitation method to enhance higher-order cognitive functions with similar mechanisms.

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Section: Discussionmentioning

confidence: 99%

80 Hz but not 40 Hz, transcranial alternating current stimulation of 80 Hz over right intraparietal sulcus increases visuospatial working memory capacity

Park

Lee

et al. 2022

Sci Rep

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“…Gamma oscillations are aberrant/disrupted in disorders like schizophrenia ( Sun et al, 2011 ; Gandal et al, 2012 ), Alzheimer’s disease and Fragile X syndrome ( Mably and Colgin, 2018 ). Non-invasive transcranial electrical stimulation techniques involving alternating current stimulation may turn out to be useful for resolving such disorders involving rhythmopathies ( Beliaeva et al, 2021 ; Frohlich and Riddle, 2021 ; Huang et al, 2021 ; Riddle et al, 2021 ; Riddle and Frohlich, 2021 ).…”

Section: Forms Of Local Field Potentialsmentioning

confidence: 99%

Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations

Sinha

Narayanan

2022

Neuroscience

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“…Evidence of additional complexity of brain stimulation effects on learning and interaction with VPL further suggests a need for a more thorough investigation of all the possible variables involved in these studies, with the goal of developing testable theoretical frameworks. Recent steps in the direction of a more integrative have been proposed, and this understanding appears crucial in moving the field forward [181].…”

Section: Closing Remarksmentioning

confidence: 99%

Perspectives on the Combined Use of Electric Brain Stimulation and Perceptual Learning in Vision

Maniglia

2022

Vision

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A growing body of literature offers exciting perspectives on the use of brain stimulation to boost training-related perceptual improvements in humans. Recent studies suggest that combining visual perceptual learning (VPL) training with concomitant transcranial electric stimulation (tES) leads to learning rate and generalization effects larger than each technique used individually. Both VPL and tES have been used to induce neural plasticity in brain regions involved in visual perception, leading to long-lasting visual function improvements. Despite being more than a century old, only recently have these techniques been combined in the same paradigm to further improve visual performance in humans. Nonetheless, promising evidence in healthy participants and in clinical population suggests that the best could still be yet to come for the combined use of VPL and tES. In the first part of this perspective piece, we briefly discuss the history, the characteristics, the results and the possible mechanisms behind each technique and their combined effect. In the second part, we discuss relevant aspects concerning the use of these techniques and propose a perspective concerning the combined use of electric brain stimulation and perceptual learning in the visual system, closing with some open questions on the topic.

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Toward integrative approaches to study the causal role of neural oscillations via transcranial electrical stimulation

Cited by 41 publications

References 99 publications

80 Hz but not 40 Hz, transcranial alternating current stimulation of 80 Hz over right intraparietal sulcus increases visuospatial working memory capacity

80 Hz but not 40 Hz, transcranial alternating current stimulation of 80 Hz over right intraparietal sulcus increases visuospatial working memory capacity

Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations

Perspectives on the Combined Use of Electric Brain Stimulation and Perceptual Learning in Vision

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