Toward Portable Artificial Kidneys: The Role of Advanced Microfluidics and Membrane Technologies in Implantable Systems

Dang, Bac Van; Taylor, Robert A.; Charlton, Alexander J.; Le‐Clech, Pierre; Barber, Tracie

doi:10.1109/rbme.2019.2933339

Cited by 18 publications

(12 citation statements)

References 192 publications

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“…Meanwhile, a portable design is crucial for wearable devices, which consist of a few components and are medium in size. Examples of portable devices are wrist‐mounted 46,47 and head‐mounted 15,48 sensors, e‐textiles, 49,50 and wearable artificial kidney (WAK) 51‐53 …”

Section: Thermal Principle and Measurement Methodsmentioning

confidence: 99%

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Thermal management of wearable and implantable electronic healthcare devices: Perspective and measurement approach

2020

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Summary The performance of electronic devices, mostly in medical applications, has been investigated to determine whether they meet the requirements of healthcare monitoring and patient's satisfaction. Mobile health monitoring is preferable at present given the current innovations in handheld, wearable, and implantable devices. However, these applications require appropriate thermal management because they are attached directly to the human body and operate for a long period. Moreover, a sophisticated design with functional mobility necessitates proper thermal circulation during the process. This review provides the current research direction for cooling systems, the thermal working principle of wearable and implantable devices, and its implementation on design architecture. Then, the importance of internal and external functional properties in thermal management and their effects on device performance are discussed. Operating temperature is among the most important elements in monitoring thermal performance due to the tendency of tissue and component damages to occur after an increment of only 1°C or 2°C in temperature. Challenges and available solutions for thermal management are listed in detail to improve cooling methods and service to the healthcare field.

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Section: Thermal Principle and Measurement Methodsmentioning

confidence: 99%

“…Examples of portable devices are wrist-mounted 46,47 and head-mounted 15,48 sensors, e-textiles, 49,50 and wearable artificial kidney (WAK). [51][52][53]…”

Section: Wearable Devicesmentioning

confidence: 99%

Thermal management of wearable and implantable electronic healthcare devices: Perspective and measurement approach

2020

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“…Indeed, the growing evidence for the efficacy and safety of longer and more frequent dialysis treatment has led a multitude of studies and new prototypes, the so-called Portable and Wearable Artificial Kidneys (PAK, WAK). The development and challenges of such highly engineered, noncell based, technologies go beyond the scope of this review and have been recently reviewed elsewhere [62][63][64]. Combining the first experiences with RAD bioengineering and new advances in miniaturization technology, a project for an Implantable RAD, or implantable bioartificial kidney, was described by Fissel and Roy [65,66].…”

Section: Bioartificial Kidneymentioning

confidence: 99%

Bioengineering strategies for nephrologists: kidney was not built in a day

Peired

Mazzinghi

Chiara

et al. 2020

Expert Opinion on Biological Therapy

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Introduction: The number of patients with end-stage kidney disease is increasing worldwide, creating an unprecedented organ shortage. The kidney is a highly complex structure performing many crucial functions. Dialysis replaces filtration but not all other kidney functions and transplant is limited by kidney availability. Numerous innovative ways are being explored to obtain new kidneys for disease modeling and potentially replace lost kidney functions. Areas covered: In this review, we will go through the different approaches that have been developed over the years to build kidneys. We will first present the current advances in xenotransplantation and generation of interspecies chimeras. Next, we will examine the attempts to create bioengineered kidneys with hemodialysis-derived implantable devices and decellularized organs. Finally, we will examine how organoids and microfluidic devices could answer important pathophysiological questions and model the path toward creating in vitro functional organs, for example through 3D bioprinting. Expert opinion: While all the aforementioned approaches to create new kidneys are promising, their translation into clinical practice seems a long way off, except xenotransplantation. Nonetheless, these novel technologies already consent disease modeling and drug testing at 3D level. We will review the stages of progress toward patient therapy and advantages/drawbacks of the various strategies.

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“…The development of wearable artificial kidneys [221,222] is of great interest for patients with kidney failure (chronic kidney disease and end-stage renal disease). The need to keep the patients connected to large systems for dialysis for prolonged periods of time is disabling, drastically altering their life, the procedure is slow and painful, and abrupt changes in blood composition may cause a shock to the patient (the so-called dialysis washout), requiring at least hours to recover.…”

Section: Wearable Artificial Kidneysmentioning

confidence: 99%

Biomimetic Nanomembranes: An Overview

Jakšić

2020

Biomimetics

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Nanomembranes are the principal building block of basically all living organisms, and without them life as we know it would not be possible. Yet in spite of their ubiquity, for a long time their artificial counterparts have mostly been overlooked in mainstream microsystem and nanosystem technologies, being a niche topic at best, instead of holding their rightful position as one of the basic structures in such systems. Synthetic biomimetic nanomembranes are essential in a vast number of seemingly disparate fields, including separation science and technology, sensing technology, environmental protection, renewable energy, process industry, life sciences and biomedicine. In this study, we review the possibilities for the synthesis of inorganic, organic and hybrid nanomembranes mimicking and in some way surpassing living structures, consider their main properties of interest, give a short overview of possible pathways for their enhancement through multifunctionalization, and summarize some of their numerous applications reported to date, with a focus on recent findings. It is our aim to stress the role of functionalized synthetic biomimetic nanomembranes within the context of modern nanoscience and nanotechnologies. We hope to highlight the importance of the topic, as well as to stress its great applicability potentials in many facets of human life.

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Toward Portable Artificial Kidneys: The Role of Advanced Microfluidics and Membrane Technologies in Implantable Systems

Cited by 18 publications

References 192 publications

Thermal management of wearable and implantable electronic healthcare devices: Perspective and measurement approach

Thermal management of wearable and implantable electronic healthcare devices: Perspective and measurement approach

Bioengineering strategies for nephrologists: kidney was not built in a day

Biomimetic Nanomembranes: An Overview

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