Toward Semi-automated Assessment of Target Volume Delineation in Radiotherapy Trials: The SCOPE 1 Pretrial Test Case

Gwynne, S.; Spezi, Emiliano; Wills, L.; Nixon, Lisette Sheena; Hurt, Chris; Joseph, George; Evans, Mererid; Griffiths, Gareth; Crosby, T.; Staffurth, John

doi:10.1016/j.ijrobp.2012.01.094

Cited by 28 publications

(29 citation statements)

References 17 publications

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“…Creating standardized agreements between “experts” is essential for the next era of radiation treatment planning quality improvement efforts, particularly if auto-segmentation algorithms are to be assessed for efficacy [20]. Already auto-segmentation or semi-automated segmentation assessment solutions are likely to become a part of radiotherapy clinical trial efforts sooner rather than later [21]. A flexible, robust software solution, capable of both manual and auto-segmentation assessment might also have applicability for both “fixed-location” [22] and “remote” [11,12] web-based training solutions that are likely to become increasingly important as the availability of new technologies increases.…”

Section: Resultsmentioning

confidence: 99%

Auto-segmentation of the brachial plexus assessed with TaCTICS – A software platform for rapid multiple-metric quantitative evaluation of contours

et al. 2015

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Section: Resultsmentioning

confidence: 99%

Auto-segmentation of the brachial plexus assessed with TaCTICS – A software platform for rapid multiple-metric quantitative evaluation of contours

et al. 2015

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“…In our results, DI scores for GTV were higher than those for boost volume, GMI scores were lower for GTV than for boost volume while other conformity indices were similar for the two structures. Generously contoured structures may be less likely to exclude any of the reference structures, and can achieve better GMI scores [22], whereas the DI is useful to highlight incorrectly large target structures, i.e. “too much unnecessary volume” [23].…”

Section: Discussionmentioning

confidence: 99%

Conformity analysis to demonstrate reproducibility of target volumes for Margin-Intense Stereotactic Radiotherapy for borderline-resectable pancreatic cancer

Holyoake

Robinson

Grose

et al. 2016

Radiotherapy and Oncology

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Background and purposeMargin-directed neoadjuvant radiotherapy for borderline-resectable pancreatic cancer (BRPC) aims to facilitate clear surgical margins. A systematic method was developed for definition of a boost target volume prior to a formal phase-I study.Material and methodsReference structures were defined by two oncologists and one radiologist, target structures were submitted by eight oncologist investigators and compared using conformity indices. Resultant risk of duodenal bleed (NTCP) was modelled.ResultsFor GTV, reference volume was 2.1 cm3 and investigator mean was 6.03 cm3 (95% CI 3.92–8.13 cm3), for boost volume 1.1 cm3 and 1.25 cm3 (1.02–1.48 cm3). Mean Dice conformity coefficient for GTV was 0.47 (0.38–0.56), and for boost volume was significantly higher at 0.61 (0.52–0.70, p = 0.01). Discordance index (DI) for GTV was 0.65 (0.56–0.75) and for boost volume was significantly lower at 0.39 (0.28–0.49, p = 0.001). NTCP using reference contours was 2.95%, with mean for investigator contour plans 3.93% (3.63–4.22%). Correlations were seen between NTCP and GTV volume (p = 0.02) and NTCP and DI (correlation coefficient 0.83 (0.29–0.97), p = 0.01).ConclusionsBetter conformity with reference was shown for boost volume compared with GTV. Investigator GTV volumes were larger than reference, had higher DI scores and modelled toxicity risk. A consistent method of target structure definition for margin-directed pancreatic radiotherapy is demonstrated.

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“…Whole volume Jaccard Conformity Index (JCI) and Geographic Miss Index (GMI) [8] were generated for both GTV and PTV comparison as described before [10], [11]. JCI is defined as the volume of the gold standard contour encompassed by the investigator contour as a fraction of their combined volume.…”

Section: Methodsmentioning

confidence: 99%

Comparison of investigator-delineated gross tumour volumes and quality assurance in pancreatic cancer: Analysis of the on-trial cases for the SCALOP trial

Fokas

Clifford

Spezi

et al. 2016

Radiotherapy and Oncology

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Background and purposeWe performed a retrospective central review of tumour outlines in patients undergoing radiotherapy in the SCALOP trial.Materials and methodsThe planning CT scans were reviewed retrospectively by a central review team, and the accuracy of investigators’ GTV (iGTV) and PTV (iPTV) was compared to the trials team-defined gold standard (gsGTV and gsPTV) using the Jaccard Conformity Index (JCI) and Geographical Miss Index (GMI). The prognostic value of JCI and GMI was also assessed. The RT plans were also reviewed against protocol-defined constraints.Results60 patients with diagnostic-quality planning scans were included. The median whole volume JCI for GTV was 0.64 (IQR: 0.43–0.82), and the median GMI was 0.11 (IQR: 0.05–0.22). For PTVs, the median JCI and GMI were 0.80 (IQR: 0.71–0.88) and 0.04 (IQR: 0.02–0.12) respectively. Tumour was completely missed in 1 patient, and ⩾ 50% of the tumour was missed in 3. Patients with JCI for GTV ⩾ 0.7 had 7.12 (95% CIs: 1.83–27.67, p = 0.005) higher odds of progressing by 9 months in multivariate analysis. Major deviations in RT planning were noted in 4.5% of cases.ConclusionsRadiotherapy workshops and real-time central review of contours are required in RT trials of pancreatic cancer.

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Toward Semi-automated Assessment of Target Volume Delineation in Radiotherapy Trials: The SCOPE 1 Pretrial Test Case

Cited by 28 publications

References 17 publications

Auto-segmentation of the brachial plexus assessed with TaCTICS – A software platform for rapid multiple-metric quantitative evaluation of contours

Auto-segmentation of the brachial plexus assessed with TaCTICS – A software platform for rapid multiple-metric quantitative evaluation of contours

Conformity analysis to demonstrate reproducibility of target volumes for Margin-Intense Stereotactic Radiotherapy for borderline-resectable pancreatic cancer

Comparison of investigator-delineated gross tumour volumes and quality assurance in pancreatic cancer: Analysis of the on-trial cases for the SCALOP trial

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