Toward the biomimetic implant surface: Biopolymers on titanium-based implants for bone regeneration

Tejero, Ricardo; Anitua, Eduardo; Orive, Gorka

doi:10.1016/j.progpolymsci.2014.01.001

Cited by 161 publications

(124 citation statements)

References 369 publications

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“…Another reason is that it is a good model of evaluation of bone remodeling and is a closed and protected cavity where the interferences with the oral environment are minimal [29,30].…”

Section: Elevation Ofmaxillary Sinus:-mentioning

confidence: 99%

“…For this, xenografts, autografts and allografts are used, with and without the use of cells [13,14]. According to the Conference of the National Institute for the Development of Health Consensus in 1982, biomaterials are beneficial organic compounds, or a combination thereof, that can be used for a period of time, wholly or partially as part of a system that treats, Replace any tissue, organ or function of the human body [18,27,30].…”

mentioning

confidence: 99%

“…This condition is maintained because the required cellular elements, cell proliferation and differentiation factors, and supramolecular structures are provided which guarantee the functional stereochemical organization of the tissues generated and their systemic integration [18,27,30].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Main Predictors on the Use of Biomaterials in Implant Dentistry: A Review.

Rodrigues.¹,

Ruis.²,

Inacio.³

et al. 2017

IJAR

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“…Another reason is that it is a good model of evaluation of bone remodeling and is a closed and protected cavity where the interferences with the oral environment are minimal [29,30].…”

Section: Elevation Ofmaxillary Sinus:-mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Main Predictors on the Use of Biomaterials in Implant Dentistry: A Review.

Rodrigues.¹,

Ruis.²,

Inacio.³

et al. 2017

IJAR

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“…Targeted functionalization of interfaces to increase biocompatibility is a widely explored approach in material science. [15][16][17][18] As shown in previous reports, using defined short bioactive sequences rather than large proteins as biological active agents, it is possible to achieve surface functionalization with defined control of biological interaction and high cell specificity. 15,23,24 However, customized interface biofunctionalization with synthetic peptides has essentially been applied to synthetic nonbiological materials as they usually have biologically inert interfaces with homogeneous surfaces allowing controlled peptide anchoring.…”

Section: Endothelialization In Vivomentioning

confidence: 99%

“…Surface functionalization with ECM-or growth factor-derived molecules is a commonly used and feasible approach to improve host cell-scaffold interactions at the interface level and enhance the biointegration of implant materials. [15][16][17][18] In the past, surface coating of engineered vascular grafts with bioactive proteins, such as fibronectin, fibrin, or vascular endothelial growth factor, has been shown to accelerate the autologous recellularization and improve graft function. [19][20][21] However, protein-based strategies may not lead to functional endothelium or prevent neointimal hyperplasia as they have been proven insufficient to elicit specific biological cues required in the process of neoendothelium formation.…”

Section: Introductionmentioning

confidence: 99%

Customized Interface Biofunctionalization of Decellularized Extracellular Matrix: Toward Enhanced Endothelialization

Aubin

Mas‐Moruno

Iijima

et al. 2016

Tissue Engineering Part C: Methods

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Interface biofunctionalization strategies try to enhance and control the interaction between implants and host organism. Decellularized extracellular matrix (dECM) is widely used as a platform for bioengineering of medical implants, having shown its suitability in a variety of preclinical as well as clinical models. In this study, specifically designed, custom-made synthetic peptides were used to functionalize dECM with different cell adhesive sequences (RGD, REDV, and YIGSR). Effects on in vitro endothelial cell adhesion and in vivo endothelialization were evaluated in standardized models using decellularized ovine pulmonary heart valve cusps (dPVCs) and decellularized aortic grafts (dAoGs), respectively. Contact angle measurements and fluorescent labeling of custommade peptides showed successful functionalization of dPVCs and dAoGs. The functionalization of dPVCs with a combination of bioactive sequences significantly increased in vitro human umbilical vein endothelial cell adhesion compared to nonfunctionalized controls. In a functional rodent aortic transplantation model, fluorescent-labeled peptides on dAoGs were persistent up to 10 days in vivo under exposure to systemic circulation. Although there was a trend toward enhanced in vivo endothelialization of functionalized grafts compared to nonfunctionalized controls, there was no statistical significance and a large biological variability in both groups. Despite failing to show a clear biological effect in the used in vivo model system, our initial findings do suggest that endothelialization onto dECM may be modulated by customized interface biofunctionalization using the presented method. Since bioactive sequences within the dECM-synthetic peptide platform are easily interchangeable and combinable, further control of host cell proliferation, function, and differentiation seems to be feasible, possibly paving the way to a new generation of multifunctional dECM scaffolds for regenerative medicine.

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Caffeic Acid‐Deferoxamine Self‐Polymerization Coating on Ti Implant Promotes Osteointegration by Synergetic Regulation of Multi‐Pathways in ONFH Mechanism

Wang

Yang

et al. 2023

Adv Funct Materials

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Osteonecrosis of the femoral head (ONFH) is a common but sophisticated multifactorial disease. In this study, the genomic characteristics of ONFH from the sequencing is first analyzed. Excepting ischemia and inflammation, some of differentially expressed genes (DEGs) are connected with autophagy. So, they are taken as the breakthrough points to design an auto polymerization coating of caffeic acid with grafting deferoxamine (DFO) and strontium on Ti substrate. In vitro cells and in vivo immunofluorescence and immunohistochemical results prove that the modified Ti can upregulate the expression of HIF-1α in mesenchymal stem cells (MSCs) and human umbilical vein endothelial cells (HUVECs) by receptors of TGF-β and TNFR on cell membrane. Interestingly, in MSCs, the upregulated HIF-1α can promote autophagy to some extent by HIF-1α/BNIP2 pathway. Meanwhile, appropriate autophagy and HIF-1α can regulate MSCs proliferation and osteogenic differentiation by STAT3/Notch pathway. However, in HUVECs, although autophagy increases slightly, the upregulated HIF-1α prefers to increase its downstream target gene VEGF and accelerate angiogenesis by the pathway of HIF-1α/VEGF. The results of in vivo implantation show that the modified Ti substrate can effectively enhance the integration effect of the implant by osteogenesis and angiogenesis. More significantly, the modified Ti can retard the further deterioration of ONFH by regulation of key genes.

show abstract

Toward the biomimetic implant surface: Biopolymers on titanium-based implants for bone regeneration

Cited by 161 publications

References 369 publications

Main Predictors on the Use of Biomaterials in Implant Dentistry: A Review.

Main Predictors on the Use of Biomaterials in Implant Dentistry: A Review.

Customized Interface Biofunctionalization of Decellularized Extracellular Matrix: Toward Enhanced Endothelialization

Caffeic Acid‐Deferoxamine Self‐Polymerization Coating on Ti Implant Promotes Osteointegration by Synergetic Regulation of Multi‐Pathways in ONFH Mechanism

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