Toward the Global Control of Human Scabies: Introducing the International Alliance for the Control of Scabies

Engelman, Daniel; Kiang, Karen; Chosidow, Olivier; McCarthy, James S.; Fuller, Claire; Lammie, Patrick J.; Hay, Roderick J.; Steer, Andrew C.

doi:10.1371/journal.pntd.0002167

Cited by 179 publications

(186 citation statements)

References 27 publications

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“…There are positive association between temperature and humidity and incidence of scabies, because of these conditions provide suitable factors for parasite growth and survival in different parts of the human body [28,29]. Scabies is consider as a one of the most prevalent skin disease in tropical areas particularly in developing countries suffering from poverty and a significant increase in the population [30][31][32]. Although the World Health Organization (WHO) classified scabies as a neglected disease, but until now it has not developed formal programs for scabies control in developing countries [33].…”

Section: Epidemiological Study Of Patients Infected With Scabies Causmentioning

confidence: 99%

Epidemiological study of patients infected with scabies caused by Sarcoptes scabiei in Al-Najaf Governorate, Iraq

Mohy¹,

Al-Hadraawy²,

Aljanaby³

2018

biomedicalresearch

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The aim of the current study was to epidemiological detection of patients infected with scabies caused by Sarcoptes scabiei during the period from March 2017 to February 2018 in Iraq, Al-Najaf Governorate.A total of 1112 patients were infected with scabies, 602 (54.1%) were men and 501 (45.9%) were female and 419 patients (37.7%) were lived in urban areas and 693 patients (62.3%) were lived in rural areas. Age group 31-40 y old was the most prevalent group (379 patients, 34%) infected with scabies. February 2018 was the highest month in infection (187 patients, 16.8%) and May 2017 was the lowest month in infection (25 patients, 2.2%). In conclusions: In Iraq, there are high numbers of individuals infected with scabies without any health care especially in rural areas. Scabies is more prevalent in cold and warmth seasons in males as well as females among age group 30-40 y old. Therefore, scabies is still an important health problem in Iraq as a neglected disease.

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Section: Epidemiological Study Of Patients Infected With Scabies Causmentioning

confidence: 99%

Epidemiological study of patients infected with scabies caused by Sarcoptes scabiei in Al-Najaf Governorate, Iraq

Mohy¹,

Al-Hadraawy²,

Aljanaby³

2018

biomedicalresearch

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“…Scabies in humans is a skin disease that affects millions of people worldwide, but it is particularly prevalent in developing countries or resource-limited populations where prevalence may be 50% or more in children, some communities, and institutions (Andrews et al 2009, Chosidow 2012, Hay et al 2012, Engelman et al 2013. It is not uncommon in the general population and in institutions in developed countries.…”

mentioning

confidence: 99%

A Proteomic Analysis ofSarcoptes scabiei(Acari: Sarcoptidae)

et al. 2016

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The pruritic skin disease scabies is caused by the burrowing of the itch mite Sarcoptes scabiei (De Geer). It is difficult to diagnose this disease because its symptoms often resemble those of other skin diseases. No reliable blood or molecular diagnostic test is available. The aim of this project was to begin to characterize the scabies proteome to identify scabies mite proteins, including those that may be useful in the development of a diagnostic test or vaccine. Various scabies mite extracts were separated by two-dimensional electrophoresis, and 844 Coomassie Blue-stained protein spots were excised, subjected to trypsin digestion, and analyzed by Matrix Assisted Laser Desorption/Ionization Time-Of-Flight/Time-Of-Flight (MALDI-TOF/TOF) mass spectrometry (MS). Tryptic fragment sequences determined by MS were searched against the recently completed S. scabiei annotated genome, leading to the identification of >150 proteins. Only 10 proteins hit to previously identified scabies proteins including actin, tropomyosin, and several ABC transporters. Thirteen proteins had homology to dust mite allergens (members of groups 8, 10, 13, 17, 20, 25, and 28). Most other sequences showed some homology to proteins in other mites and ticks including homologs of calmodulin, calreticulin, lipocalin, and glutathione-Stransferase. These data will now allow the identification of the proteins to which scabies patients produce antibodies, including those that may be good candidates for inclusion in a diagnostic test and vaccine.

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“…Ruam pada kulit berawal dengan terjadinya papulae eritrema (penonjolan kulit tanpa berisi cairan, berbentuk bulat, berbatas tegas, berwarna merah, ukuran <1 cm) yang terus berkembang menjadi vesicle atau pustule (penonjolan kulit berisi cairan atau nanah). Adanya terowongan di bawah lapisan kulit merupakan ciri khas dari infestasi tungau ini (McCarthy, et al, 2004;Engelman, et al, 2013).…”

Section: Gambar 2 Predileksi (Area) Infestasi Tungauunclassified

“…Sarcoptes scabiei mampu memproduksi substansi proteolitik (sekresi saliva) yang berperan dalam pembuatan terowongan, aktivitas makan, dan melekatkan telurnya pada terowongan tersebut. Reaksi hipersensitifitas tipe IV dapat menimbulkan nodul (bentuk papule dengan ukuran yang lebih besar) dan bulla (bentuk vesicle dengan ukuran yang lebih besar) pada area di mana tidak ditemukan tungau pada kulit (McCarthy, et al, 2004;Engelman, et al, 2013). Nodul biasanya ditemukan di daerah selangkangan, bokong, dan pusar (Walton dan Currie, 2007).…”

Section: Gambar 2 Predileksi (Area) Infestasi Tungauunclassified