2014
DOI: 10.1002/cyto.b.21187
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Toward the harmonization of result presentation for the eosin-5′-maleimide binding test in the diagnosis of hereditary spherocytosis

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Cited by 26 publications
(34 citation statements)
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“…However, we found a raised cut-off point when compared to other studies [11,12]. Probably, the limited number of patients with HS, and the fact of their clinical condition be classified between moderate to severe [4] may explain the results found. Accordingly, the cut-off point of 6.4% might not be used in the trait or mild HS, making it necessary for more studies to include HS individuals with all disease conditions (both homozygous and heterozygous).…”
Section: Discussioncontrasting
confidence: 76%
See 1 more Smart Citation
“…However, we found a raised cut-off point when compared to other studies [11,12]. Probably, the limited number of patients with HS, and the fact of their clinical condition be classified between moderate to severe [4] may explain the results found. Accordingly, the cut-off point of 6.4% might not be used in the trait or mild HS, making it necessary for more studies to include HS individuals with all disease conditions (both homozygous and heterozygous).…”
Section: Discussioncontrasting
confidence: 76%
“…Currently, it is not indicated due to its low sensitivity, leading to false negative results with the presence of other causes of anemia [2]. The eosin-5-maleimide (EMA) by binding test is performed by flow cytometry (FC) and has a sensitivity of 99%, but the reactants used are unstable and costly [4][5][6]. Flowcytometric osmotic fragility test (FCM OF) is another method by FC, which evaluates the resistance of RBC to lysis after being exposed to deionized water.…”
Section: Introductionmentioning
confidence: 99%
“…Visual evaluation of the tracing may reveal tailing as in our Case 3, representing a subset of highly fragile red cells that are conditioned by the spleen [10]. The EMA-dye binding test has rapidly established itself as a very useful adjunct, especially in such diagnostically ambiguous situations [11].…”
Section: Discussionmentioning
confidence: 92%
“…This option (involving an invasive sampling procedure) is only considered when other types of anemia with similar presentation and phenotype have been excluded in a diagnostic work-up. Furthermore, some CDAII can give positive test results in the Eosin-5 0 -maleimide (EMA) binding test (a screening test for HS) (19,20). Some CDAII patients are misdiagnosed to have hereditary spherocytosis (HS) due to occasional spherocytes on the blood smear (17).…”
Section: Introductionmentioning
confidence: 99%