Toward the mechanisms of auditory attention

Hromádka, Tomáš; Zador, Anthony M.

doi:10.1016/j.heares.2007.01.002

Cited by 25 publications

(10 citation statements)

References 26 publications

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“…Wires were inserted into the 75 cortex until the tips of the electrodes were 0.5-0.8 mm 76 below the dura, while viewing through a microscope and 77 listening to an audio monitor of the recorded signal. The Circulating corticosterone measurement activity has been reported to be modulated by attention 576 (Hroma´dka and Zador, 2007;Otazu et al, 2009 We found that the effect of acute restraint stress showed 583 a continuous distribution between enhancement and 584 suppression in the AC neuron population (Fig. 2) (Galea et al, 1997;SC and CL, 2004;Pe´rez et al, 2013).…”

Section: Introductionmentioning

confidence: 83%

Acute restraint stress alters sound-evoked neural responses in the rat auditory cortex

Zhang

Yang

et al. 2015

Neuroscience

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Section: Introductionmentioning

confidence: 83%

Acute restraint stress alters sound-evoked neural responses in the rat auditory cortex

Zhang

Yang

et al. 2015

Neuroscience

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“…AI neurons in an awake state showed lower spike-timing fidelity and followed lower AM rates than those in an anesthetized state (Ter-Mikaelian et al, 2007). It also has been shown that task-engagement and attention can modulate neural responses including temporal response aspects (Fritz et al, 2005; Hromadka and Zador, 2007). More detailed studies of effects of alertness and attention on RRTFs and MTFs are necessary.…”

Section: Discussionmentioning

confidence: 99%

Spatial organization of repetition rate processing in cat anterior auditory field

et al. 2011

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Auditory cortex updates incoming information on a segment by segment basis for human speech and animal communication. Measuring repetition rate transfer functions (RRTFs) captures temporal responses to repetitive sounds. In this study, we used repetitive click trains to describe the spatial distribution of RRTF responses in cat anterior auditory field (AAF) and to discern potential variations in local temporal processing capacity. A majority of RRTF filters are band pass. Temporal parameters estimated from RRTFs and corrected for characteristic frequency or latency dependencies are non-homogeneously distributed across AAF. Unlike the shallow global gradient observed in spectral receptive field parameters, transitions from loci with high to low temporal parameters are steep. Quantitative spatial analysis suggests non-uniform, circumscribed local organization for temporal pattern processing superimposed on global organization for spectral processing in cat AAF.

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“…The behavioral paradigm two-alternative choice task (2-ACT) is used to study auditory attention in rats (Otazu et al, 2009; Jaramillo and Zador, 2011; Znamenskiy and Zador, 2013; Xiong et al, 2015). In this paradigm, auditory attention is associated with increases in neural activity in A1, which is required to process information of attention (Hromádka and Zador, 2007; Xiong et al, 2015). As well, behavioral and electrophysiological studies have shown a significant positive association between the animal’s performances in the attentional task and increased activity in A1 (Xiong et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Reboxetine Improves Auditory Attention and Increases Norepinephrine Levels in the Auditory Cortex of Chronically Stressed Rats

Pérez-Valenzuela

Gárate‐Pérez

Sotomayor‐Zárate

et al. 2016

Front. Neural Circuits

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Chronic stress impairs auditory attention in rats and monoamines regulate neurotransmission in the primary auditory cortex (A1), a brain area that modulates auditory attention. In this context, we hypothesized that norepinephrine (NE) levels in A1 correlate with the auditory attention performance of chronically stressed rats. The first objective of this research was to evaluate whether chronic stress affects monoamines levels in A1. Male Sprague–Dawley rats were subjected to chronic stress (restraint stress) and monoamines levels were measured by high performance liquid chromatographer (HPLC)-electrochemical detection. Chronically stressed rats had lower levels of NE in A1 than did controls, while chronic stress did not affect serotonin (5-HT) and dopamine (DA) levels. The second aim was to determine the effects of reboxetine (a selective inhibitor of NE reuptake) on auditory attention and NE levels in A1. Rats were trained to discriminate between two tones of different frequencies in a two-alternative choice task (2-ACT), a behavioral paradigm to study auditory attention in rats. Trained animals that reached a performance of ≥80% correct trials in the 2-ACT were randomly assigned to control and stress experimental groups. To analyze the effects of chronic stress on the auditory task, trained rats of both groups were subjected to 50 2-ACT trials 1 day before and 1 day after of the chronic stress period. A difference score (DS) was determined by subtracting the number of correct trials after the chronic stress protocol from those before. An unexpected result was that vehicle-treated control rats and vehicle-treated chronically stressed rats had similar performances in the attentional task, suggesting that repeated injections with vehicle were stressful for control animals and deteriorated their auditory attention. In this regard, both auditory attention and NE levels in A1 were higher in chronically stressed rats treated with reboxetine than in vehicle-treated animals. These results indicate that NE has a key role in A1 and attention of stressed rats during tone discrimination.

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Toward the mechanisms of auditory attention

Cited by 25 publications

References 26 publications

Acute restraint stress alters sound-evoked neural responses in the rat auditory cortex

Acute restraint stress alters sound-evoked neural responses in the rat auditory cortex

Spatial organization of repetition rate processing in cat anterior auditory field

Reboxetine Improves Auditory Attention and Increases Norepinephrine Levels in the Auditory Cortex of Chronically Stressed Rats

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