Toward Understanding on the Regulatory Network of HBx-induced microRNA-187-5p in Hepatocellular Carcinoma: A Study based on Bioinformatics Analysis

Wang, La; Xu, Chang; Sun, Dandan; Deng, Yang; Wei, Xinyue; Zhou, Jun

doi:10.1145/3473258.3473285

Cited by 1 publication

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“…E2F transcriptional activity is regulated by transcriptional and translational processes, post-translational changes, and protein degradation throughout the cell cycle. Based on bioinformatic research, we discovered that HBx inhibits miR-187-5p expression in HCC cell lines [ 24 ]. The association between HBx and miR-187-5p and the mechanism underneath triggered our interest.…”

Section: Introductionmentioning

confidence: 99%

HBx promotes hepatocellular carcinoma progression by repressing the transcription level of miR-187-5p

Deng,

Wang,

Zhang

et al. 2023

Aging

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HBV-associated hepatitis B virus x protein (HBx) plays multiple roles in the development of hepatocellular carcinoma. In our prior study, we discovered that miR-187-5p expression was inhibited by HBx. To investigate the underlying molecular mechanism of HBx-mediated miR-187-5p downregulation in hepatocellular carcinoma cells, effects of HBx and miR-187-5p on hepatoma carcinoma cell were observed, as well as their interactions. Through in vitro and in vivo experiments, we demonstrated that overexpression of miR-187-5p inhibited proliferation, migration, and invasion. Simultaneously, we observed a dysregulation in the expression of miR-187-5p in liver cancer cell lines, which may be attributed to transcriptional inhibition through the E2F1/FoxP3 axis. Additionally, we noted that HBx protein is capable of enhancing the expression of E2F1, a transcription factor that promotes the expression of FoxP3. In conclusion, our results suggest that the inhibitory effect of HBx on miR-187-5p is mediated through the E2F1/FoxP3 axis. As shown in this work, HBx promotes hepatoma carcinoma cell proliferation, migration, and invasion through the E2F1/FoxP3/miR-187 axis. It provides a theoretical basis for finding therapeutic targets that will help clinic treatment for HCC.

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Section: Introductionmentioning

confidence: 99%