Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors

Lah, Tamara T.; Nanni, Isabelle; Trinkaus, Miha; Metellus, P.; Dussert, Christophe; Ridder, Leo De; Rajčević, Uroš; Blejec, Andrej; Martin, Pièrre‐Marie

doi:10.3171/2009.7.jns081729

Cited by 21 publications

(11 citation statements)

References 32 publications

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“…Glioma cells were positioned close to the long retinal axons obtained derived from explants of embryonic chickens. Migration of cancer cells has been monitored by confocal microscopy and high-resolution video microscopy [255]. Overall, the invasiveness results obtained by confrontation assay are correlated with malignancy in vivo [256].…”

Section: D Models For Testing Motility/invasion Of Cns Tumorsmentioning

confidence: 99%

“…The advantages consist in a better representation of the invasion process, due to the fluorescent tag applied to the tumor cells, as well as in a better representation of extracellular matrix molecules normally encountered by invading glioma cells [133,222]. Oellers and collaborators described a similar refined protocol [255], presenting a co-culture of glioma cells with myelinated axons in vitro, with the aim to study the interactions between migrating glioma cells and nerve fibers. Glioma cells were positioned close to the long retinal axons obtained derived from explants of embryonic chickens.…”

Section: D Models For Testing Motility/invasion Of Cns Tumorsmentioning

confidence: 99%

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In Vitro Modeling of Tissue-Specific 3D Microenvironments and Possibile Application to Pediatric Cancer Research

Pizzimenti¹

2014

J. Pediatr. Oncol.

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A large body of evidence indicates that three dimensional (3D) cancer models are superior to two-dimensional (2D) ones in better representing the in vivo phenomena. Indeed, 3D models allow recapitulating in vitro the in vivo features observed in solid tumors (e.g. cell polarity, cell-cell/cell-matrix interactions, biochemical/metabolic gradients, anchorage-independent growth and hypoxia). Moreover, it is well established that the microenvironment plays a fundamental role in regulating tumor development and behavior, including drug resistance. Thus, innovative models able to mimic this complexity represent attractive tools in cancer research. In this review article, we provide a comprehensive review of the application of 3D culture systems in pediatrics' cancer research. In particular, 3D in vitro/ex vivo models of the most common pediatric tumors, such as leukemias, lymphomas and malignancies of the nervous system, will be considered.

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Section: D Models For Testing Motility/invasion Of Cns Tumorsmentioning

confidence: 99%

Section: D Models For Testing Motility/invasion Of Cns Tumorsmentioning

confidence: 99%

In Vitro Modeling of Tissue-Specific 3D Microenvironments and Possibile Application to Pediatric Cancer Research

Pizzimenti¹

2014

J. Pediatr. Oncol.

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“…Further studies are required to clarify the significance of the appearance of Rosenthal fibers. No difference in MIB-1 staining index was seen between cases of true and pseudo-invasion, and the question of whether any sort of difference in cellular activity exists between the two remains a matter for further study, although there are several reports up to now [5] [6].…”

Section: Discussionmentioning

confidence: 94%

Reconsideration of So-Called “Invasive” Meningioma

Okada

Fujitsu²,

Ichikawa³

et al. 2015

OJMN

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For the purpose of histopathological diagnosis, so-called "invasive meningioma" is defined as a meningioma that has infiltrated the cerebral parenchyma, and such cortical infiltration raises the risk of recurrence. However, as the definition of "invasive" remains far from clear, we have attempted to redefine it. Tumors that were completely removed from 32 patients between April 2005 and September 2015 and that had been diagnosed as so-called "invasive meningioma" were classified by World Health Organization grade (Group I-III), and then further classified as: true invasion, involving invasion of the brain with breakdown of the pia mater; and pseudo-invasion, involving encroachment into the brain with the pia mater still intact. We then investigated recurrence rates in the brain or dura mater for each group. Rate of recurrence in the brain or dura mater was significantly higher for Group I meningioma classified as true invasion compared to that of the same group classified as pseudo-invasion. We redefined so-called "invasive meningioma" as Group I meningioma exhibiting true invasion, and considered that, when possible, wide resection of the areas of adhesion to the dura mater in addition to tumor extirpation along with the cerebral parenchyma increased the success rate for curative treatment.

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“…Desmosomes are crucial for tissue homoeostasis and cardiac integrity . The cysteine protease inhibitors stefins have been proposed as prognostic and diagnostic tools for cancer and may have an important role in desmosome‐mediated cell–cell adhesion . The role of this regulatory family in the heart is unknown and warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Folic acid reduces doxorubicin‐induced cardiomyopathy by modulating endothelial nitric oxide synthase

Octavia

Kararigas

Boer

et al. 2017

J Cellular Molecular Medi

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The use of doxorubicin (DOXO) as a chemotherapeutic drug has been hampered by cardiotoxicity leading to cardiomyopathy and heart failure. Folic acid (FA) is a modulator of endothelial nitric oxide (NO) synthase (eNOS), which in turn is an important player in diseases associated with NO insufficiency or NOS dysregulation, such as pressure overload and myocardial infarction. However, the role of FA in DOXO‐induced cardiomyopathy is poorly understood. The aim of this study was to test the hypothesis that FA prevents DOXO‐induced cardiomyopathy by modulating eNOS and mitochondrial structure and function. Male C57BL/6 mice were randomized to a single dose of DOXO (20 mg/kg intraperitoneal) or sham. FA supplementation (10 mg/day per oral) was started 7 days before DOXO injection and continued thereafter. DOXO resulted in 70% mortality after 10 days, with the surviving mice demonstrating a 30% reduction in stroke volume compared with sham groups. Pre‐treatment with FA reduced mortality to 45% and improved stroke volume (both P < 0.05 versus DOXO). These effects of FA were underlain by blunting of DOXO‐induced cardiomyocyte atrophy, apoptosis, interstitial fibrosis and impairment of mitochondrial function. Mechanistically, pre‐treatment with FA prevented DOXO‐induced increases in superoxide anion production by reducing the eNOS monomer:dimer ratio and eNOS S‐glutathionylation, and attenuated DOXO‐induced decreases in superoxide dismutase, eNOS phosphorylation and NO production. Enhancing eNOS function by restoring its coupling and subsequently reducing oxidative stress with FA may be a novel therapeutic approach to attenuate DOXO‐induced cardiomyopathy.

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Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors

Cited by 21 publications

References 32 publications

In Vitro Modeling of Tissue-Specific 3D Microenvironments and Possibile Application to Pediatric Cancer Research

In Vitro Modeling of Tissue-Specific 3D Microenvironments and Possibile Application to Pediatric Cancer Research

Reconsideration of So-Called “Invasive” Meningioma

Folic acid reduces doxorubicin‐induced cardiomyopathy by modulating endothelial nitric oxide synthase

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