Towards a Better Understanding of Endometriosis-Related Infertility: A Review on How Endometriosis Affects Endometrial Receptivity

Abstract

Endometriosis is the most common cause of infertility. Endometrial receptivity has been suggested to contribute to infertility and poor reproductive outcomes in affected women. Even though experimental and clinical data suggest that the endometrium differs in women with endometriosis, the pathogenesis of impaired endometrial receptivity remains incomplete. Therefore, this review summarizes the potential mechanisms that affect endometrial function and contribute to implantation failure. Contemporary data regarding hormone imbalance, inflammation, and immunoregulatory dysfunction will be reviewed here. In addition, genetic, epigenetic, glycosylation, metabolism and microRNA in endometriosis-related infertility/subfertility will be summarized. We provide a brief discussion and perspectives on their future clinical implications in the diagnosis and therapy to improve endometrial function in affected women.

Hysteroscopy with Endometrial Vacuum Aspiration in Repeated Implantation Failure: Diagnostic Significance and the Effect on IVF Success

“…Так, при изучении структуры патологии матки у пациенток с RIF полип эндометрия встречался в 3,9-35,6 % случаев, миома матки -0,3-15,3 %, спаечный процесс в матке -4,5-22,1 %, пороки развития -2,4-5,7 % случаев [8][9][10][11][12]. Значительный контраст с данными других авторов в вопросе частоты выявления патологии матки на гистероскопии связан с тем, что заключения «эндометриоз матки» и «эндометрит» не включались в отчеты исследователей, хотя имеются данные о связи этих состояний с нарушением процесса имплантации [13][14][15].…”

CREB1 Is Involved in miR-134-5p-Mediated Endometrial Stromal Cell Proliferation, Apoptosis, and Autophagy

“…Compared with normal endometrial tissues, CREB1 has a higher expression level in ectopic endometrial tissues, and it affects endometrial cell motility, growth, and invasion under endometriosis (EMS) [35,36]. In addition, patients with clinically diagnosed EMS typically have reduced endometrial receptivity, expressed as abnormal expression of endometrial genes, sex hormone receptors, and cell adhesion molecules [37]. In our experiments, a significantly higher expression of CREB1 was observed during the follicular phase in comparison to the luteal phase.…”

“…The transcription factor cAMP response element-binding protein-1 (CREB1), as an important target for multiple signaling pathways, was reported to be markedly dysregulated in endometriosis (EMS) patients [35,36]. Endometrial receptivity has been found to decline in patients clinically diagnosed with EMS [37]. Therefore, we speculate that dysregulation of CREB1 may affect endometrial receptivity.…”

The effect of pentoxifylline and different types of exercise training on coagulation factors in a rat endometriosis model

“…Pentoxifylline (PTX), a prevalent treatment method, is an anti-inflammatory and immunomodulatory agent that is recommended for treating endometriosis. Animal studies indicated that PTX significantly suppressed the development of ectopic lesions [14] . PTX alters the transcriptional control of proinflammatory genes 15 , 16 .…”