It is commonly seen that accessibility is measured considering only one opportunity or activity type or purpose of interest, e.g., jobs. The value of a location, and thus the overall access, however, depends on the ability to reach many different types of opportunities. This paper clarifies the concept of multi-activity accessibility, which combines multiple types of opportunities into a single aggregated access measure, and aims to find more comprehensive answers for the questions: what is being accessed, by what extent, and how it varies by employment status and by gender. The Minneapolis -St. Paul metropolitan region is selected for the measurement of multi-activity accessibility, using both primal and dual measures of cumulative access, for auto and transit. It is hypothesized that workers and non-workers, and males and females have different accessibility profiles. This research demonstrates its practicality at the scale of a metropolitan area, and highlights the differences in access for workers and nonworkers, and men and women, because of differences in their activity participation.