The goal of our study is to present a systematic modeling framework for the identification of water vapor plumes in plasma and magnetic field data from spacecraft flybys of Europa. In particular, we determine the degree to which different plume configurations can be obscured by the interaction of Jupiter's magnetospheric plasma with Europa's induced dipole field and its global atmosphere. We apply the hybrid model AIKEF (kinetic ions, fluid electrons) to investigate the effect of inhomogeneities in Europa's atmosphere (plumes) on the plasma interaction with the Jovian magnetosphere. To systematically assess the magnitude and structure of the perturbations associated with the plume-plasma interaction at Europa, we vary the plume location across Europa's surface while considering different symmetric and asymmetric density profiles of the moon's global atmosphere. To isolate the impact of a plume on Europa's magnetospheric environment, we also conduct model runs without any global atmosphere. To quantify the magnetic perturbations caused by plumes, we analyze the field components along hypothetical spacecraft trajectories through each plume. Conclusions of our study are (1) localized regions of stagnant flow are most indicative of the presence of a plume. (2) The visibility of plumes in the magnetic field strongly depends on the density profile (whether it is symmetric or asymmetric) of the global atmosphere. (3) The presence of an induced dipole complicates the identification of magnetic signatures associated with a plume and dominates Europa's magnetic environment in its intermediate vicinity. (4) Complex fine structures are visible in the tail of escaping plume ions.magnetospheric plasma interacts with the (time-varying) dipole field induced in the moon's subsurface ocean (Kivelson et al., 1999;Zimmer et al., 2000), which is driven by the 9.6 • tilt between Jupiter's magnetic and rotational axes. This induced dipole field is compressed at Europa's ramside and stretched at its wakeside, locally contributing to transverse currents and therefore to the Alfvén wings (Liuzzo et al., 2016). The coupling of the dipole-magnetosphere interaction and the ionospheric mass loading reduces the cross section of the Alfvén wings and generates a slight displacement of the wings with respect to the moon (Neubauer, 1999;Volwerk et al., 2007).However, the view of Europa's neutral gas environment was changed drastically when, in December 2012, Hubble Space Telescope (HST) observations of the moon's UV aurora revealed a localized surplus of UV emission intensity near its south pole, associated with an increase in oxygen and hydrogen column densities. Roth et al. (2014) showed that two water vapor plumes emanating near 180 • W 75 • S and 55 • S, each with a scale height of about 200 km, quantitatively match the HST observations. Through image postprocessing, Sparks et al. (2016) found hints of additional transient plumes, located near the south pole at 271 • W 63 • S and in the equatorial region at 275.7 • W 16.4 • S. However, subsequ...