Towards a Molecular Model of Nerve Excitability

Neumann, Eberhard

doi:10.1007/978-3-642-66012-2_29

Biochemistry of Sensory Functions 1974

DOI: 10.1007/978-3-642-66012-2_29

|View full text |Cite

Towards a Molecular Model of Nerve Excitability

Eberhard Neumann

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1976

1985

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Das �bertragungsverhalten der neuromuskul�ren synapse: Deutung experimenteller befunde durch ein modell

Fritzsche

1985

Biol. Cybern.

View full text Add to dashboard Cite

A model of neuromuscular transmission has been proposed which considers morphological structure and interrelated chemical and electrical mechanisms. The adequate kinetic scheme has been described by means of a system of nonlinear first order differential equations and the network of corresponding electrical processes has been treated as a linear first order differential equation with one variable coefficient. By the analytical investigation of derived differential equations detailed informations about the qualitative behaviour of the solutions were obtained. Present results of modelling characterize the neuromuscular synapse as a "perfect" transfer element, since all the possible dynamic solutions tend to exactly one singular point - the "resting state", independent of initial values and all other parameters. The special time-dependent solutions simulated by computer with biologically relevant parameters are in good agreement with experimentally determined transient response of the neuromuscular synapse. The paper concludes with an outlook of the possible pharmacologic application of the developed model.

show abstract

Das �bertragungsverhalten der neuromuskul�ren synapse: Deutung experimenteller befunde durch ein modell

Fritzsche

1985

Biol. Cybern.

View full text Add to dashboard Cite

show abstract

Nerve excitability: Transition from descriptive phenomenology to chemical analysis of mechanisms

Nachmansohn

1977

Klin Wochenschr

View full text Add to dashboard Cite

The electrical activity by which impulses are conducted along nerve and muscle fibers, is carried by Na-and K-ions moving across the excitable membranes due to increased ion permeability. -- A biochemical approach, initiated to elucidate the mechanism of the permeability changes, centered around the analysis of the properties and functions of the proteins, including enzymes, directly associated with the role of AcCh, in the excitable membrane. The results necessitated a fundamentally reformed concept of the role of AcCh. The four proteins specifically associated with the function of AcCh form a cycle which controls the rapid ion permeability changes of the membrane and permits the ion fluxes through dynamic gateways. A model has been elaborated that integrates biochemical, biophysical, and thermodynamic data; it permits the interpretation of many electrophysiological data in molecular terms. AcCh has basically the same function in conducting and synaptic parts of excitable membranes. The new concept has replaced the purely descriptive phenomenology of nerve impulse propagation by the analysis of the chemical mechanisms of nerve excitability and bioelectricity.

show abstract

Distribution of diisopropylphosphorofluoridate‐hydrolyzing enzyme between sheath and axoplasm of squid giant axon

Hoskin

1976

Journal of Neurochemistry

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Towards a Molecular Model of Nerve Excitability

Cited by 3 publications

References 58 publications

Das �bertragungsverhalten der neuromuskul�ren synapse: Deutung experimenteller befunde durch ein modell

Das �bertragungsverhalten der neuromuskul�ren synapse: Deutung experimenteller befunde durch ein modell

Nerve excitability: Transition from descriptive phenomenology to chemical analysis of mechanisms

Distribution of diisopropylphosphorofluoridate‐hydrolyzing enzyme between sheath and axoplasm of squid giant axon

Contact Info

Product

Resources

About