Towards a new strategy of a chitosan‐based molecularly imprinted membrane for removal of 4‐nitrophenol in real water samples

Bello, Maria Pia Di; Mergola, Lucia; Scorrano, Sonia; Sole, Roberta Del

doi:10.1002/pi.5360

Cited by 32 publications

(17 citation statements)

References 39 publications

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“…In this study, we attempted to develop a system that prevents time‐consuming pretreatments that require highly specialized operators. In particular, starting from the experience of our research group , molecular imprinting technology (MIT) was chosen to obtain a polymer selective for l ‐Kyn to be employed as a sorbent material in an SPE device to extract and purify endogenous l ‐Kyn before HPLC analysis. Thus, the matrix effect could be greatly reduced and the use of MS detector could be substituted with a less expensive and more accessible detection system such as a diode array detector (DAD).…”

Section: Introductionmentioning

confidence: 99%

Urinary l‐kynurenine quantification and selective extraction through a molecularly imprinted solid‐phase extraction device

Mergola

Orabona

Albini

et al. 2018

J of Separation Science

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l-Kynurenine is an endogenous metabolite generated by the catabolic pathway of l-tryptophan and it could be a potential biomarker to test the efficacy of several checkpoint inhibitors that have already reached the clinical trials in the antitumor therapy. Thus, a molecularly imprinted polymer specific for the recognition of this metabolite was synthesized and used as innovative system in solid-phase extraction technique for the specific extraction and quantification of l-kynurenine in human urine. The off-line system was firstly tested on l-kynurenine standard solutions, allowing recoveries up to 97.7% (relative standard deviation = 2.2%) and then applied to fortified and deproteinated human urine samples, where a recovery of 84.1% (relative standard deviation = 3.1%) was obtained. The method was validated and it revealed a good linearity in the range of 0.157-20 μg/mL (r = 0.9992). The optimized procedure demonstrated a good feasibility on biological samples, allowing a ready quantification of l-kynurenine in the human urine, where the metabolite was found at a very low concentration (0.80 μg/mL). The extraction system developed could attract attention of pharmaceutical industries for l-kynurenine production as potential drug in the treatment of autoimmune disorders through its extraction and purification from biological matrixes.

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Section: Introductionmentioning

confidence: 99%

Urinary l‐kynurenine quantification and selective extraction through a molecularly imprinted solid‐phase extraction device

Mergola

Orabona

Albini

et al. 2018

J of Separation Science

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“…All chemicals were used without further purification. PABSA was prepared according to our previously reported procedure [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

“…PABSA was prepared according to our previously reported procedure [ 22 ]. CS solution was prepared by dissolving 85.2 mg of CS into 3 mL of aqueous acetic acid solution (1% v / v ) and stirred until complete dissolution.…”

Section: Methodsmentioning

confidence: 99%

“…Wang et al hypothesized that an azobenzene derivative may participate in the adsorption process through the coordination of an ion metal with π electrons of –N=N–. In a very recent work, a chitosan-based, molecularly imprinted membrane for the removal of 4-nitrophenol was prepared in our laboratory [ 22 ]. However, azo-based CS material has never been used in ion-imprinted polymer systems.…”

Section: Introductionmentioning

confidence: 99%

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A New Ion-Imprinted Chitosan-Based Membrane with an Azo-Derivative Ligand for the Efficient Removal of Pd(II)

Bello¹,

Lazzoi

Mele

et al. 2017

Materials

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Herein, we described the synthesis of a novel ion-imprinted membrane for the detection of palladium(II) prepared through the glutaraldehyde crosslinking of chitosan with a 4-[(4-Hydroxy)phenylazo]benzenesulfonic acid ligand trapped into the membrane. The imprinting technology was used to improve adsorption capacity and adsorption selectivity, and was combined with some advantages of the developed membrane, such as low cost and ease of preparation, water-friendly synthesis, and high biocompatible chitosan material. The membranes were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Energy Dispersive X-ray Spectrometry (EDS). The results obtained showed a high swelling ratio with a maximum value of 16.4 (1640%) at pH 4 with a strong pH dependence. Batch rebinding experiments gave a maximum adsorption capacity of 101.6 mg of Pd(II) per gram of imprinted membrane. The Pd(II) adsorption behavior was well-described by a Langmuir model with a theoretical maximum adsorption capacity of 93.48 mg g−1, similar to the experimental one. Finally, a selectivity study versus Ag(I), Pb(II), and Fe(III) ions demonstrated a good selectivity of chitosan-imprinted membrane towards Pd(II).

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“…15,16 Continuous monitoring of solution to investigate the adsorption kinetics was achieved using a circulating pump and an interferometer, 10 but the device is quite complex and not suitable for common adsorption systems. Adsorption of 4-nitrophenol on chitosan-based molecularly imprinted membrane was measured in situ in the cuvette by Di Bello in 2017, 17 but this method is only suitable for the systems which have sufficient optically transparent window and for a volume of no more than few milliliters. In order to reduce the measurement procedure, some scholars applied adsorption bag made by nylon mesh and other materials in the batch adsorption and achieved direct determination of solution concentration without centrifugation or filtration at equilibrium.…”

Section: Introductionmentioning

confidence: 99%

In Situ Liquid-Phase-Adsorption Measurement System Based on Fiber-Optic Sensing with the Aid of Membranes

et al. 2018

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At present, liquid phase adsorption (LPA) is still being quantitatively characterized in the way of manual sampling and off-line determination because of the complexity of the system comparing to gas adsorption. This paper describes a novel method for in situ, real-time measurement of LPA in general based on fiber-optic sensing (FOS) with the aid of membranes for the first time. A self-made measurement vessel was assembled from an adsorption bag, thermostatic devices with a stirrer, and a fiber-optic dipping probe. Also, macroporous adsorption resins (MARs) and rutin were chosen as model adsorbent and adsorbate to establish the FOS system. Here, in situ light absorption measurement was achieved by eliminating interference of adsorbent particles via encapsulating them with a membrane into the adsorption bag. In situ LPA measurement of rutin solution on MARs was obtained by detecting light absorption at 353 nm using dipping probe, in the broad concentration range from 0.3 to 60 mg/L with excellent linearity ( R 2 = 0.9996). In situ measurements of adsorption and desorption kinetics on five kinds of MARs with different polarities were systematically carried out, showing that the adsorption process obeyed the pseudo-second-model. As well as, the system was proved to be highly accurate and reproducible. More importantly, this method enabled to study the initial stage of the adsorption process, starting from the time of the first second, which is the most important part in the adsorption kinetics, and this is impossible for traditional sampling methods. The successful application of FOS to in situ measurement of LPA not only contributes to fast, automatic, and real-time monitoring of LPA process but also enriches the research connotation of adsorption.

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Towards a new strategy of a chitosan‐based molecularly imprinted membrane for removal of 4‐nitrophenol in real water samples

Cited by 32 publications

References 39 publications

Urinary l‐kynurenine quantification and selective extraction through a molecularly imprinted solid‐phase extraction device

Urinary l‐kynurenine quantification and selective extraction through a molecularly imprinted solid‐phase extraction device

A New Ion-Imprinted Chitosan-Based Membrane with an Azo-Derivative Ligand for the Efficient Removal of Pd(II)

In Situ Liquid-Phase-Adsorption Measurement System Based on Fiber-Optic Sensing with the Aid of Membranes

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