Current accounts of spatial cyberinfrastructure development tend to overemphasize technologies to the neglect of critical social and cultural issues on which adoption depends. Spatial cyberinfrastructures will have a higher chance of success if users of many types, including nonprofessionals, are made central to the development process. Recent studies in the history of infrastructures reveal key turning points and issues that should be considered in the development of spatial cyberinfrastructure projects. These studies highlight the importance of adopting qualitative research methods to learn how users work with data and digital tools, and how user communities form. The author's empirical research on data sharing networks in the Pacific Northwest salmon crisis at the turn of the 21st century demonstrates that ordinary citizens can contribute critical local knowledge to global databases and should be considered in the design and construction of spatial cyberinfrastructures.C yberinfrastructure (CI) will simultaneously transform the technical tools and the social arrangements of contemporary scientific work according to the Atkins Report (1) of the National Science Foundation (NSF). Following the models of modern biological or climate change research, many sciences will become datadriven, relying on high-performance computing grids capable of processing, analyzing, storing, and indexing enormous datasets. Cross-disciplinary collaboration among teams of geographically dispersed researchers will become more prevalent. Spatial cyberinfrastructure (spatial CI) or CyberGIS, as the similar research trend in geographic information science (GIScience) is alternately referred to, combines the tools and computing technologies of CI with the power of spatial analysis to address complex environmental and social issues such as climate change, disaster response, transportation planning, and national security. Although the use of CI in GIScience is relatively recent, there is an important tradition of spatial data infrastructure research that emphasizes the social aspects of online data sharing and interoperability among data communities. In addition, the recent efflorescence of Internet mapping by private companies, mapping agencies, and ordinary citizens, commonly referred to as the geospatial web (2) can be a resource for GIscientists as they undertake the development of spatial CIs. Spatial CIs can contribute new insights to the more general CI effort by promoting research on the social and organizational aspects of infrastructure development and by demonstrating the important role that ordinary citizens might play in CI.To date, writings on technical and social transformations projected to result from CI and spatial CI efforts have focused on professional scientists. Both the way scientists work and how they interact with others are expected to change. Crossdisciplinary collaborations will become the norm and they will require new technologies to support interactive virtual environments, shared analytical tools, and in sili...