Introduction Evidence-based practice is a problem-based solving approach to clinical practice that encourages nurses providing personalized patient care while utilizing the necessary scientific evidence for a better understanding of risks and benefits of diagnostic tests and treatments. Digital transformation of an organization begins with attaining an acceptable digital readiness level. One approach entails specifying and modeling their processes and the respective data models. Objectives In Jordan, at King Hussein Cancer Center—an international and regional accredited cancer care hospital—their nursing practice requires obtaining a standardized specification of evidence-based practice processes and their respective conceptual data model that is currently not specified for digital readiness. Methods The design science research methodology was adopted to deliver two increments. The first was concerned with the design, development, and demonstration of eight evidence-based practice processes specified using BPMN. The second was related to the design and development, demonstration, and evaluation of a respective derived data model of the case study. Both increments involved interviews with domain experts for elicitation and validation. Results Eight evidence-based practice process models were identified and specified using BPMN along with their associated data models, where one representative process model was utilized in this research to demonstrate the effectiveness of process and data modeling towards digital readiness of evidence-based practice in regional cancer center. Conclusions Both deliverables enabled the evidence-based practice management to attain common understanding to identify inefficiencies, redundancies, and areas for improvement that can be addressed through digital solutions. Evidence -based practice BPMN process models were considered as a road map to follow up a project implementation and a rich visualization to perform data analytics to identify evidence-based practice trends, patterns, and insights that can inform strategic data-driven decisions. Both deliverables were concluded necessary for developing respective information systems in the journey towards digital transformation.
