The aim of this paper is to contribute to a prospective science and technology assessment (ProTA) of synthetic biology in order to enable an early societal shaping of this emerging wave of technoscience. To accomplish this goal, a philosophical approach towards the technoscientific core of synthetic biology-provided by philosophy of science and philosophy of technology-will be taken. The thesis is that if there is any differentia specifica giving substance to the umbrella term "synthetic biology", it is the idea(l) of harnessing self-organization for engineering purposes. To underline that we are likely experiencing an epochal break in the ontology of technoscientific systems, this new type of technology is called "late-modern technology." I start by analyzing the three most common paradigms and visions of synthetic biology (Sect. 2). Then I argue that one particular paradigm deserves more attention because it underlies the others: the paradigm of self-organization (Sect. 3). However, synthetic biology does not stand alone in making use of self-organization; it is a governing vision in robotics, ubiquitous computing, nano-and neuro-technologies (Sect. 4). Further, I show that instabilities constitute the conditions and, hence, the technoscientific core of selforganization (Sect. 5). Given the relevance of instabilities, I consider the inherent limits of late-modern (self-organization) technology in construction/design and control/monitoring, and in particular I elaborate why it is so difficult to control biosynthetic systems (Sect. 6). I end by drawing conclusions for the early-stage approach of ProTA and sum up the characteristics of late-modern technology as a challenging subject area of philosophy of technology (Sects. 7 and 8).