Towards a Richer Debate on Tissue Engineering: A Consideration on the Basis of NEST-Ethics

Oerlemans, Anke; Hoek, M. E. C.; Leeuwen, Evert van; Burg, Simone van der; Dekkers, W.J.M.

doi:10.1007/s11948-012-9419-y

Cited by 18 publications

(37 citation statements)

References 94 publications

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“…Yet, in practice, it does not always succeed to serve that goal. It has been noted, more often, that public discussion about new technologies often repeats and reaffirms well-known moral points of view in a somewhat mantra-like fashion [21, 28]. This happens also in lay ethics interventions.…”

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confidence: 86%

A Lay Ethics Quest for Technological Futures: About Tradition, Narrative and Decision-Making

Burg

2016

Nanoethics

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Making better choices about future technologies that are being researched or developed is an important motivator behind lay ethics interventions. However, in practice, they do not always succeed to serve that goal. Especially authors who have noted that lay ethicists sometimes take recourse to well-known themes which stem from old, even ‘archetypical’ stories, have been criticized for making too little room for agency and decision-making in their approach. This paper aims to contribute to a reflection on how lay ethics can acquire more practical relevance. It will use resources in narrative ethics to suggest that in order to be relevant for action, facilitators of lay ethics interventions need to invite participants to engage in a narrative quest. As part of a quest, lay ethicists should be asked to (1) reflect on a specific question or choice, (2) use diverse (imaginative) input which is informative about the heterogeneity of viewpoints that are defended in society and (3) argue for their standpoints.

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confidence: 86%

A Lay Ethics Quest for Technological Futures: About Tradition, Narrative and Decision-Making

Burg

2016

Nanoethics

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“…Of course many other examples can be given of situations in which relations to different future activities provide a different way to look at present activities and the technologies that they give rise to. See, for example, Krabbenborg (2013), Oerlemans et al (2013), and van der Burg (2009).…”

Section: Notesmentioning

confidence: 99%

On the hermeneutic need for future anticipation

Burg¹

2014

Journal of Responsible Innovation

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“…Despite the excellent efficacy, this strategy is limited by high manufacturing costs and possible security issues (1). In the field of bone tissue engineering, bone marrow is one of the most important source of seed cells, as mesenchymal stem cells (MSCs) derived from bone marrow have been universally recognized for their multi-lineage differentiation potentials and reliable reparative capacity (2,3).…”

Section: Introductionmentioning

confidence: 99%

The Osteogenetic Efficacy of Goat Bone Marrow-Enriched Self-Assembly Peptide/Demineralized Bone MatrixIn VitroandIn Vivo

Hou²,

Deng³

et al. 2015

Tissue Engineering Part A

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In clinical practice, the prolonged duration, high cost, critical technique requirements, and ethical issues make the classical construction method of tissue-engineered bones difficult to apply widely. The major essentials in tissue engineering strategies include seed cells, growth factors, and scaffolds. This study aimed to incorporate these factors in a rapid and cost-effective manner. A self-assembly peptide/demineralized bone matrix (SAP/DBM) composite was artificially established and used for bone marrow enrichment via a selective cell retention approach. Then, goat mesenchymal stem cells (gMSCs) were seeded onto the SAP/DBM or DBM. The proliferation status of gMSCs in different scaffolds was analyzed, and the osteogenetic efficacy was evaluated after osteogenic induction. Bilateral critical-sized femoral defects (20-mm in length) were created in goats, and then the defects were implanted with the postenriched composite or DBM. Then, bone scan imaging, micro-computed tomography (CT) analysis and histological examination were performed to assess the reparative effects of the different implants. Compared with the DBM scaffolds, the growth of gMSCs in the postenriched SAP/DBM composite was faster and the expression levels of the osteo-specific genes (i.e., alkaline phosphatase, osteocalcin, osteopontin, and runt-related transcription factor 2) were significantly higher after 14 days of osteogenic induction. More importantly, the postenriched SAP/DBM composite significantly enhanced bone metabolic activity in the defect area compared with DBM at 2 and 4 weeks postoperation. Moreover, bone reconstruction was complete in marrow-enriched SAP/DBM composite, but not in the DBM. In addition, all of the osteo-related parameters, including the ratio of bone volume to total bone volume, bone mineral density, new trabecular number, and new trabecular thickness, were significantly higher in the marrow-enriched SAP/DBM than those in the DBM. These results indicated that the SAP/DBM composite held great potential for clinical applications; immediate implantation after marrow enrichment could be a new and effective strategy for treating bone defect.

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Towards a Richer Debate on Tissue Engineering: A Consideration on the Basis of NEST-Ethics

Cited by 18 publications

References 94 publications

A Lay Ethics Quest for Technological Futures: About Tradition, Narrative and Decision-Making

A Lay Ethics Quest for Technological Futures: About Tradition, Narrative and Decision-Making

On the hermeneutic need for future anticipation

The Osteogenetic Efficacy of Goat Bone Marrow-Enriched Self-Assembly Peptide/Demineralized Bone MatrixIn VitroandIn Vivo

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