Towards a systems level analysis of health and nutrition

Naylor, Stephen; Culbertson, Adam; Valentine, Stephen J.

doi:10.1016/j.copbio.2008.02.009

Cited by 21 publications

(13 citation statements)

References 65 publications

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“…Furthermore, more applied research fields benefit from SB tools and strategies. Examples can be found in the fields of nutrition and health (Naylor et al 2008), drug discovery (Sakata and Winzeler 2007;Tan et al 2007;Strong and Eisenberg 2007), medicine (Lemberger 2007;Smithies 2005;Winzeler 2006;Xiong et al 2005), research on cancer (Ao et al 2008;Benvenuti et al 2005;Cui et al 2007) and on schizophrenia (Middleton et al 2007). …”

Section: Applying Modelling Practices To Other Organisms and Disciplinesmentioning

confidence: 98%

Ins and Outs of Systems Biology vis-à-vis Molecular Biology: Continuation or Clear Cut?

2009

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The comprehension of living organisms in all their complexity poses a major challenge to the biological sciences. Recently, systems biology has been proposed as a new candidate in the development of such a comprehension. The main objective of this paper is to address what systems biology is and how it is practised. To this end, the basic tools of a systems biological approach are explored and illustrated. In addition, it is questioned whether systems biology 'revolutionizes' molecular biology and 'transcends' its assumed reductionism. The strength of this claim appears to depend on how molecular and systems biology are characterised and on how reductionism is interpreted. Doing credit to molecular biology and to methodological reductionism, it is argued that the distinction between molecular and systems biology is gradual rather than sharp. As such, the classical challenge in biology to manage, interpret and integrate biological data into functional wholes is further intensified by systems biology's use of modelling and bioinformatics, and by its scale enlargement.

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Section: Applying Modelling Practices To Other Organisms and Disciplinesmentioning

confidence: 98%

Ins and Outs of Systems Biology vis-à-vis Molecular Biology: Continuation or Clear Cut?

2009

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“…This is the reason for complaints about the resulting knowledge fragmentation [61,62]. The problem shall be solved with (i) the help of holism [61], (ii) nutritional system biology [63] and (iii) with the aim of evolutionary medicine [62,[64][65][66][67][68].…”

Section: Nutritional Science -Scientific Status Quomentioning

confidence: 99%

Molecularization in nutritional science: A view from philosophy of science

Schmeißer

Döring

2010

Molecular Nutrition Food Res

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Methodologically, molecular nutrition research is bound to a microreductive research approach. We emphasize, however, that it need not be a radical microreductionism whose scientific reputation is not the best. Instead we favor moderate microreductionism, which combines reduction with integration. As mechanismic explanations are one of the primary aims of factual sciences, we consider it as the task of molecular nutrition research to find profound, i.e. molecular-mechanismic, explanations for the conditions, characteristics and changes of organisms related to the organism-nutrition environment interaction.

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“…Computational analysis of biological processes, using information technology (IT), might play a key role in the advent of personalized medicine [66]. In particular, we observe the following specific contributions of IT to tailored therapy: (i) the ability to integrate genomic, molecular, and epigenetic data about each individual patient in a unified framework, (ii) the capability to effectively analyze this information using complex queries and data mining methods, and (iii) to apply computational procedures that predict the patient's response to treatment based on his or her genomic make-up, epigenetic tendencies, and environmental data.…”

Section: Data Integration and The Computational Analysis Of Biologicamentioning

confidence: 99%