The evolution of ontological engineering leaded authors to use some techniques of software engineering to design ontologies. Are obtained from these techniques the monolithic or modularized Ontologies. When is difficult to reuse some concepts of monolithic ontologies, modularized Ontologies facilitate ontology management, understandability and reuse. This paper aims to survey on ontology modularization techniques and their contribution in biomedical ontologies design. Modularization reposed on appropriated techniques and some challenges related to ontology reused, scalable querying, collaborative authoring, and distributed reasoning. For most of disease ontologies, more especially ontologies which reused IDO, these challenges are not considered, and most of them are implemented with OWL language and the novel mode to construct ontology’s purpose is to facilitate reuse and interoperability of ontologies ensured by modularization.