Serendipity is fundamental to science. This quirky and intriguing phenomenon permeates across scientific disciplines, including the medical sciences, psychological sciences, management and organizational sciences, innovation science, philosophy and library and information sciences. Why is it so ubiquitous? Because of what it facilitates and catalyzes: scientific discoveries from velcro to Viagra, innovation of all forms, unexpected encounters of useful information, novel and important ideas, and deep reflection on how we, as individuals, organizations, communities and societies can take leaps forwards by seizing unexpected opportunities and ‘making our own luck.’