‘Towards a unified approach for the determination of the bioaccessibility of organic pollutants’

Collins, Christopher D.; Craggs, Mark; Garcia‐Alcega, Sonia; Kademoglou, Katerina; Lowe, Stephen

doi:10.1016/j.envint.2015.02.005

Cited by 70 publications

(37 citation statements)

References 79 publications

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“…Bioaccessibility is an important tool to estimate the oral availability, i.e. the proportion of the bioaccessible fraction that potentially reaches the systemic circulation (Collins et al, 2015;Versantvoort et al, 2005). The assessment of bioaccessibility is fundamental for risk-benefit analysis of nutrients and contaminants associated to food consumption, providing more accurate information and guidelines for food consumption to authorities, industry and consumers (Cardoso et al, 2013;Maulvault et al, 2013;Maulvault et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Oral bioaccessibility of toxic and essential elements in raw and cooked commercial seafood species available in European markets

et al. 2018

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The oral bioaccessibility of several essential and toxic elements was investigated in raw and cooked commercially available seafood species from European markets. Bioaccessibility varied between seafood species and elements. Methylmercury bioaccessibility varied between 10 (octopus) and 60% (monkfish). Arsenic (>64%) was the toxic element showing the highest bioaccessibility. Concerning essential elements bioaccessibility in raw seafood, selenium (73%) and iodine (71%) revealed the highest percentages. The bioaccessibility of elements in steamed products increased or decreased according to species. For example, methylmercury bioaccessibility decreased significantly after steaming in all species, while zinc bioaccessibility increased in fish (tuna and plaice) but decreased in molluscs (mussel and octopus). Together with human exposure assessment and risk characterization, this study could contribute to the establishment of new maximum permissible concentrations for toxic elements in seafood by the European food safety authorities, as well as recommended intakes for essential elements.

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Section: Introductionmentioning

confidence: 99%

Oral bioaccessibility of toxic and essential elements in raw and cooked commercial seafood species available in European markets

et al. 2018

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“…carpets, electronic appliances and 52 furniture polyurethane foam) (Dodson et al, 2012;European Commission, 2003) and their to contaminated indoor dust on a wide spectrum of HOCs including brominated flame 83 retardants (BFRs) (Abdallah et al, 2012), organophosphate FR (OPFRs) ; 84 Quintana et al, 2017), pesticides and polychlorinated biphenyls (PCBs) (Ertl and Butte,85 2012) and polybrominated diphenyl ethers (PBDEs) (Yu et al, 2012). However, the lack of 86 an adsorption sink in the various test formats may lead to risk underestimation due to the 87 absence of constant concentration gradient (Collins et al, 2015). Sink conditions better 88 mimic the sorption/desorption processes in the human GIT in vivo and, coupled with the .…”

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confidence: 99%

Bioaccessibility of PBDEs present in indoor dust: A novel dialysis membrane method with a Tenax TA® absorption sink

Kademoglou

Williams

Collins

2018

Science of The Total Environment

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Human uptake of flame retardants (FRs) such as polybrominated diphenyl ethers (PBDEs) via indoor dust ingestion is commonly considered as 100% bioaccessible, leading to potential risk overestimation. Here, we present a novel in vitro colon-extended physiologically-based extraction test (CE-PBET) with Tenax TA® as an absorptive "sink" capable to enhance PBDE gut bioaccessibility. A cellulose-based dialysis membrane (MW cut-off 3.5kDa) with high pH and temperature tolerance was used to encapsulate Tenax TA®, facilitating efficient physical separation between the absorbent and the dust, while minimizing re-absorption of the ingested PBDEs to the dust particles. As a proof of concept, PBDE-spiked indoor dust samples (n=3) were tested under four different conditions; without any Tenax TA® addition (control) and with three different Tenax TA® loadings (i.e. 0.25, 0.5 or 0.75g). Our results show that in order to maintain a constant sorptive gradient for the low MW PBDEs, 0.5g of Tenax TA® are required in CE-PBET. Tenax TA® inclusion (0.5g) resulted in 40% gut bioaccessibility for BDE153 and BDE183, whereas greater bioaccessibility values were seen for less hydrophobic PBDEs such as BDE28 and BDE47 (~60%). When tested using SRM 2585 (n=3), our new Tenax TA® method did not present any statistically significant effect (p>0.05) between non-spiked and PBDE-spiked SRM 2585 treatments. Our study describes an efficient method where due to the sophisticated design, Tenax TA® recovery and subsequent bioaccessibility determination can be simply and reliably achieved.

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“…Oral bioaccessibility measures the fraction of compounds which are desorbed from the ingested matrix into the gastrointestinal fluids in vitro (Collins et al, 2015), providing an estimation of bioavailability (EPA), 2007). Bioaccessibility studies avoid the use of animal experiments, which are ethically and economically problematic, difficult to conduct and still may not represent human conditions (Hamel et al, 1999;Oomen et al, 1999;Ruby et al, 1993;Ruby et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Does the source migration pathway of HBCDs to household dust influence their bio-accessibility?

Garcia‐Alcega

Rauert

Harrad

et al. 2016

Science of The Total Environment

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A study was conducted to assess the human bioaccessibility of dust contaminated with hexabromocyclododecane (HBCD) via two migration pathways a) volatilisation with subsequent partitioning to dust particles, and b) abrasion of treated textile fibres directly to the dust. This was achieved using previously developed experimental chamber designs to generate dust samples contaminated with HBCDs emitted from a HBCD treated textile curtain. The generated dust samples were exposed to an in vitro colon extended physiologically based extraction test (CE-PBET). The bioaccessibility of the HBCDs which were incorporated within dust as a result of volatilisation from the curtain material with subsequent partitioning to dust was higher than in dusts contaminated with HBCDs via abrasion of the curtain (35% and 15% respectively). We propose this occurs due to a stronger binding of HBCDs to treated fabric fibres than that experienced following volatilisation and sorption of HBCDs to dust particles.

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‘Towards a unified approach for the determination of the bioaccessibility of organic pollutants’

Cited by 70 publications

References 79 publications

Oral bioaccessibility of toxic and essential elements in raw and cooked commercial seafood species available in European markets

Oral bioaccessibility of toxic and essential elements in raw and cooked commercial seafood species available in European markets

Bioaccessibility of PBDEs present in indoor dust: A novel dialysis membrane method with a Tenax TA® absorption sink

Does the source migration pathway of HBCDs to household dust influence their bio-accessibility?

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