Towards a unified model of event-related potentials as phases of stimulus-to-response processing

Taylor, Brittany K.; Gavin, William J.; Grimm, Kevin J.; Prince, Mark A.; Lin, Mei‐Heng; Davies, Patricia L.

doi:10.1016/j.neuropsychologia.2019.107128

Cited by 7 publications

(14 citation statements)

References 49 publications

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“…Still, our study may motivate future investigations of these bodily aspects of psychedelic effects, in consideration of this and other neurophysiological mechanisms. Additionally, a single process early in the neural processing stream (e.g., N100) may further modulate later stages through co‐dependent temporal properties of the signal (Burgess, 2012; Taylor et al, 2019). The disembodiment aspect may also further modulate perception through a lessened corporeal reference and desynchronization of predictive coding (Giummarra, Gibson, Georgiou‐Karistianis, & Bradshaw, 2008; Ho, Preller, & Lenggenhager, 2020).…”

Section: Discussionmentioning

confidence: 99%

P300‐mediated modulations in self–other processing under psychedelic psilocybin are related to connectedness and changed meaning: A window into the self–other overlap

Smigielski

Kometer

Scheidegger

et al. 2020

Human Brain Mapping

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The concept of self and self‐referential processing has a growing explanatory value in psychiatry and neuroscience, referring to the cognitive organization and perceptual differentiation of self‐stimuli in health and disease. Conditions in which selfhood loses its natural coherence offer a unique opportunity for elucidating the mechanisms underlying self‐disturbances. We assessed the psychoactive effects of psilocybin (230 μg/kg p.o.), a preferential 5‐HT1A/2A agonist known to induce shifts in self‐perception. Our placebo‐controlled, double‐blind, within‐subject crossover experiment (n = 17) implemented a verbal self‐monitoring task involving vocalizations and participant identification of real‐time auditory source‐ (self/other) and pitch‐modulating feedback. Subjective experience and task performance were analyzed, with time‐point‐by‐time‐point assumption‐free multivariate randomization statistics applied to the spatiotemporal dynamics of event‐related potentials. Psilocybin‐modulated self‐experience, interacted with source to affect task accuracy, and altered the late phase of self‐stimuli encoding by abolishing the distinctiveness of self‐ and other‐related electric field configurations during the P300 timeframe. This last effect was driven by current source density changes within the supragenual anterior cingulate and right insular cortex. The extent of the P300 effect was associated with the intensity of psilocybin‐induced feelings of unity and changed meaning of percepts. Modulations of late encoding and their underlying neural generators in self‐referential processing networks via 5‐HT signaling may be key for understanding self‐disorders. This mechanism may reflect a neural instantiation of altered self–other and relational meaning processing in a stimulus‐locked time domain. The study elucidates the neuropharmacological foundation of subjectivity, with implications for therapy, underscoring the concept of connectedness.

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Section: Discussionmentioning

confidence: 99%

P300‐mediated modulations in self–other processing under psychedelic psilocybin are related to connectedness and changed meaning: A window into the self–other overlap

Smigielski

Kometer

Scheidegger

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…This concept of interrelated phases of neural processing has been proposed and examined in Taylor et al. (2019), who have shown the feasibility of modeling ERPs as a full sequence of systemic neural processing (N1 → P2 → N2 → P3 → E‐wave) to predict response times (RTs) in a cued Go/NoGo task collected on two sessions in typical developing children using structural equation modeling (SEM). The findings not only demonstrated that the stream of neural processes was predictive of task behavior (i.e., averaged response times), but also suggested that the model which simultaneously accounted for trait‐based (e.g., sex and age) as well as session‐specific state measures of sources of individual variability yielded better model fit compared to the model which only accounted for trait measures.…”

Section: Introductionmentioning

confidence: 99%

“…Based on the adaptive orienting theory proposed by Wessel (2018) and the model structure established by Taylor et al. (2019), we tested four conceptual models (Figure 1) using ERP data collected from typically developing children ages 8–12 years old performing a speeded flanker task. In this study, two types of path models were tested.…”

Section: Introductionmentioning

confidence: 99%

“…Taylor et al. (2019) reported that models including the state effect yielded better model fit compared to models which did not include the state effect. Additionally, the latent state variable of session 1 was predictive of the latent state variable of session 2 ( β = .56), indicating that the state effect systematically influenced the ERPs across sessions.…”

Section: Introductionmentioning

confidence: 99%

“…Based on Taylor et al. (2019), we hypothesized that the state effect is systematic across sessions such that subjects' state on session 1 is predictive of their state on session 2. We also hypothesized that by accounting for the state effect, the results should yield better model fit compared to models without the state effect.…”

Section: Introductionmentioning

confidence: 99%

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Modeling electrophysiological measures of decision‐making and performance monitoring in neurotypical children engaging in a speeded flanker task

et al. 2021

Self Cite

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This study aims to use structural equation modeling (SEM) to investigate the role of error processing in behavioral adaptation in children by testing relationships between error‐related and stimulus‐related event‐related potentials (ERPs) obtained from two sessions of a speeded Eriksen flanker task. First, path models of averaged ERP components and mean response times (N1 → P2 → N2 → P3 → RTs) while controlling for trait effects, age, and sex, on each was examined separately for correct and incorrect trials from each session. While the model demonstrated acceptable fit statistics, the four models yielded diverse results. Next, path models for correct and incorrect trials were tested using latent variables defined by factoring together respective measures of ERP component amplitudes from each session. Comparison of correct and incorrect models revealed significant differences in the relationships between the successive measures of neural processing after controlling for trait effects. Moreover, latent variable models controlling for both trait and session‐specific state variables yielded excellent model fit while models without session‐specific state variables did not. In the final model, the error‐related neural activity (i.e., the ERN and Pe) from incorrect trials was found to significantly relate to the stream of neural processes contributing to trials with the correct behavior. Importantly, the relationship between RT and error detection in the final model signifies a brain‐and‐behavior feedback loop. These findings provided empirical evidence that supports the adaptive orienting theory of error processing by demonstrating how the neural signals of error processing influence behavioral adaptations that facilitate correct behavioral performance.

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Neural oscillations underlying selective attention follow sexually divergent developmental trajectories during adolescence

Taylor

Eastman

Frenzel

et al. 2021

Developmental Cognitive Neuroscience

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Towards a unified model of event-related potentials as phases of stimulus-to-response processing

Cited by 7 publications

References 49 publications

P300‐mediated modulations in self–other processing under psychedelic psilocybin are related to connectedness and changed meaning: A window into the self–other overlap

P300‐mediated modulations in self–other processing under psychedelic psilocybin are related to connectedness and changed meaning: A window into the self–other overlap

Modeling electrophysiological measures of decision‐making and performance monitoring in neurotypical children engaging in a speeded flanker task

Neural oscillations underlying selective attention follow sexually divergent developmental trajectories during adolescence

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