Tomato (Solanum lycopersicum L.) is the most consumed vegetable and one of the most studied crops in the world. Over the years, several technologies have been studied and applied to crop production towards higher productivity, quality, and production efficiency. This chapter reviews greenhouse tomato production, cropping systems, and environmental conditioning, focusing on technological developments and the latest reclaimed water trends that have started to take off in the context of increasing water scarcity due to climate change. Following worldwide research trends and policies, the influence of the different technologies in fresh tomato production and the use of reclaimed water or reuse of treated nutrient solution is explored as it is expected to be a great advance in the Mediterranean region in the next years, and it is of the utmost importance, as the region increasingly suffers from climate change effects.